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生物标志物生物标志物

Pauline Maillard¹, Prashanthi Vemuri², Heather M Snyder³

¹Department of Neurology and Center for Neuroscience, University of California, Davis, Davis, CA, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association

|December 25, 2025

概括

这项研究发现,心血管疾病 (CVD) 图像标志物,血管风险因素 (VRF) 和两个队列的认知之间存在一致的关系. 这些发现支持MRI标记器用于评估大脑健康和VRF影响的概括性.

科学领域:

神经成像是一种神经成像.
心血管疾病研究研究
认知神经科学认知神经科学

背景情况:

心血管疾病 (CVD) 通过各种机制影响大脑结构和功能.
研究了四种MRI标记物 (自由水,微分异构,周脉空间,白质超强度) 及其与血管风险因素 (VRF) 和认知相关性的研究.
研究了这些关联在不同队列中的通用性.

研究的目的:

评估四个心血管疾病和VRF的MRI标志物之间的关系的概括性.
检查这些MRI标记物与认知功能之间的关联.
为了比较POINTER和Framingham心脏研究 (FHS) 队列之间的发现.

主要方法:

分析了907名POINTER和797名FHS参与者的基线人口统计,临床和成像数据.
回归分析评估年龄,性别,高血压,糖尿病和吸烟对MRI标记物的影响.
线性回归用于评估MRI标记物与认知结果之间的关联,并对共变量进行调整.

主要成果:

尽管存在队列差异,但VRF和MRI标志物 (例如年龄,高血压,糖尿病) 之间发现了一致的关联.
认知能力下降与分数异构性 (FA) 降低和自由水量 (FW) 增加有关.
白质超强度 (WMH) 和周血管空间 (PVS) 与认知结果没有显著关联.

结论:

四个MRI标记物代表了对大脑结构和功能的多种CVD影响.
跨队伍的CVD标记物,VRF和认知之间的一致关系支持概括性.
这些发现加强了这些MRI标记器在理解心血管疾病对大脑健康的影响方面的实用性.

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