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相关概念视频

Infection01:20

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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基础科学和病原发生学

Soohyun Park1,2, Anthony H Mark1, Eilis W Reardon2

  • 1Tufts University School of Medicine, Boston, MA, USA.

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PubMed
概括
此摘要是机器生成的。

早期的创伤,如父母虐待,削弱了老年非洲裔美国人对认知和认知功能的遗传倾向之间的积极联系. 创伤知情护理对于这一群体的认知健康至关重要.

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科学领域:

  • 神经科学是一个神经科学.
  • 遗传学 是一个遗传学.
  • 公共卫生 公共卫生

背景情况:

  • 非洲裔美国人 (AAs) 面临更高的阿尔茨海默氏症和痴呆率以及认知健康差异.
  • 现有的AA研究探讨了遗传风险 (APOE) 和早期创伤,但多基因评分对一般认知 (PGS-gc) 的作用及其与创伤的相互作用尚未研究.

研究的目的:

  • 研究PGS-gc和早期创伤对老年AA的认知功能的主要和附加效应.
  • 检查早期创伤是否会缓解PGS-gc与老年AAs认知功能之间的关联.

主要方法:

  • 从健康和退休研究 (1996-2020) 的1174名非洲血统成年人 (50+) 的纵向生长曲线建模.
  • 认知功能通过总认知得分进行评估.
  • PGS-gc测量了遗传倾向;通过不良童年经历评估早期创伤.

主要成果:

  • 较高的PGS-gc与更好的认知功能显著相关 (z = 2.59,p < .05).
  • 16岁之前的家庭丧失与较低的认知功能有关,独立于PGS-gc (z = -2.49,p < .05).
  • 父母虐待显著缓解了PGS-gc-认知联系,减弱了暴露于创伤的个体中的关联 (z = -2.53,p < .05).

结论:

  • 早期的创伤,特别是父母的虐待,适度和削弱了多基因倾向和认知功能之间的积极关系在老年AAs.
  • 调查结果强调了对创伤预防和创伤相关护理的关键需求,以提高认知健康并减少种族/种族少数群体中老年人的差异.