痴呆症护理研究和心理社会因素
Vitório Serafim1, Gabrielle Guindani Maia1, Leonardo Bedatti Koehler2
1Fundação Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
超直流刺激 (tDCS) 显示出改善初级渐进性失言症 (PPA) 的命名能力的希望. 然而,对语音产生的影响不是长期持续的,功能连接反应因性别和年龄而异.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 医疗干预 医疗干预
背景情况:
- 初级渐进性失言症 (PPA) 是一种影响语言的神经退行性疾病.
- PPA有三种变体:语言 (lvPPA),语义 (svPPA) 和非流利/语法 (nfvPPA).
- 超直流刺激 (tDCS) 是一种非侵入性脑刺激技术.
研究的目的:
- 系统地审查TDCS对PPA患者的影响.
- 分析tDCS在不同PPA变体中的疗效.
- 调查影响PPA中tDCS结果的因素.
主要方法:
- 在PubMed,Embase和Cochrane数据库中进行系统搜索.
- 包括随机对照试验 (RCT) 在PPA患者中评估tDCS.
- 两个研究人员对标题和摘要进行独立审查.
主要成果:
- 五项涉及119名患者的RCT符合纳入标准.
- tDCS在命名子测试中显示出显著的改善,特别是在脊侧前额叶皮层的阳极刺激下.
- 在PPA变体之间没有观察到tDCS效应的显著差异. 功能连接反应因性别和年龄而异,女性和老年人有负面影响. 观察到能量和语音生产的短期改善,但不是持续的.
- 应用于背侧前额皮质的阳道tDCS显示,随着时间的推移 (p=0.018) 在命名子测试和在12周和24周的命名准确性 (p=0.049,p=0.030) 中显著改善.
- 在其他大脑区域的高清tDCS并没有显著改变整体失言症得分 (p=0.14),但命名子测试显示了积极的影响 (p=0.02).
- 在女性中,tDCS显著降低了语言网络中的功能连接 (FC) (p<0.001),衰老与减少的FC有关 (p=0.009).
- 能源和语音生产的短期改善被注意到,但并没有长期持续.
结论:
- tDCS有效地改善了PPA患者的命名能力.
- 没有证明tDCS对能量和语音产生有持续的长期影响.
- 对tDCS的功能连接反应受性别和年龄等个体因素的影响.
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