生物标志物 生物标志物
Johannes C Michaelian1,2, Azadeh Feizpour3, James C Vickers4
1Healthy Brain Ageing Program, Brain and Mind Centre, School of Psychology, Faculty of Science, University of Sydney, Camperdown, NSW, Australia.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
一项新的阿尔茨海默病 (AD) 血液检测显示,它有望提高诊断准确度. 这项测试测量了血pTau181水平,增加了临床医生对诊断AD的信心,特别是在早期阶段.
科学领域:
- 神经学 神经学
- 生物标志物发现发现
- 诊断医学 诊断医学 诊断医学
背景情况:
- 最近的进展使得阿尔茨海默病 (AD) 生物标志物的血液检测成为可能.
- 非侵入性,具有成本效益的AD血液测试可以改善早期诊断和治疗启动.
研究的目的:
- 通过血pTau181水平揭示AD概率对临床医生的诊断信心和管理的影响.
- 评估在临床环境中新型血液检测的有用性.
主要方法:
- 在澳大利亚三个记忆和认知诊所进行了一项前后研究.
- 使用Quanterix SimoaTM平台测量了pTau181的血水平.
- 对临床医生来说,结果被报告为可能是负面的,不确定的或可能是积极的.
主要成果:
- 参与了113名患有痴呆症,轻度认知障碍或主观认知衰退的参与者.
- 血液检测结果在12.4%的病例中改变了诊断,使临床医生的信心从63.1%增加到78.6%.
- 三分之二的临床医生支持临床使用这种血液测试,并进一步改进.
结论:
- 血pTau181血液测试有可能提高临床实践中的诊断准确性.
- 该研究表明,在患者最初的低至中等信心水平的情况下,诊断信心得到了改善.
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