生物标志物 生物标志物
Julia Kearley1, Bratislav Misic2, Maria Natasha Rajah1
1Toronto Metropolitan University, Toronto, ON, Canada.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
更年期和血管风险显著改变大脑连接,更年期后的女性显示出更大的脆弱性. 了解这些变化对于老年妇女的认知健康策略至关重要.
科学领域:
- 神经科学是一个神经科学.
- 血管生物学 血管生物学
- 衰老研究研究 衰老研究
背景情况:
- 更年期相关的荷尔蒙变化会影响血管健康和大脑功能,特别是休息状态功能连接 (rsFC).
- 雌激素的下降与记忆力缺陷和改变的认知网络有关.
- 血管风险因素可能会在绝经后妇女中加剧这些影响,强调需要了解它们对rsFC的影响.
研究的目的:
- 调查血管风险因素如何影响男性与女性的rsFC.
- 检查中年女性的更年期状态是否会改变这些关联.
- 为了确定与血管风险相关的群体特定的rsFC模式.
主要方法:
- 从绝经前,绝经后和男性参与者收集 rs-fMRI 数据.
- 使用感兴趣的皮质和海马体区域计算的FC矩阵.
- 使用两组B-PLS分析与血管风险因素 (BMI,胆固醇,血压等) 作为行为向量.
主要成果:
- 两种性别都显示了高胆固醇和定期炼的改变 rsFC;男性也与BMI相关,女性与BP和年龄相关.
- 女性独特地显示了注意力和控制/默认模式网络之间的 rsFC 增加,与胆固醇,血压,年龄和运动有关.
- 在女性中,这些影响主要是由绝经后的个体驱动的.
结论:
- 性别和更年期状态显著调节了血管风险和rsFC之间的关系.
- 绝经后的女性对与血管风险相关的rsFC变化具有更高的脆弱性,影响对认知至关重要的网络.
- 血管风险因素对男性和女性的rsFC有不同的影响,BMI是显著的差异化因素.
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