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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
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智能响应型PLGA-ES100复合纳米粒子载有Resolvin E1用于炎症调节行为.

Maolin Sun1,2, Yi Han1,2, Leila Mamizadehjanghour3

  • 1Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, Sichuan, China.

ACS applied bio materials
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概括

这项研究开发了适应pH值的纳米颗粒,在性条件下释放抗炎性Resolvin E1 (RvE1),改善生物降解植入物周围的免疫反应控制并减少纤维化.

关键词:
在PLGA-Eudragit S100纳米粒子中.一个RvE1调节炎症 调节炎症巨细胞的行为对于pH值敏感的物质

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科学领域:

  • 生物材料科学 生物材料科学
  • 免疫调节是一种免疫调节.
  • 药物输送系统 药物输送系统

背景情况:

  • 可生物降解的植入物需要在植入部位进行精确的免疫调节控制.
  • 合金在降解过程中产生性环境,对免疫反应构成挑战.
  • 目前的策略缺乏对免疫反应的时空控制.

研究的目的:

  • 在性环境中设计响应pH的纳米粒子,用于控制药物释放.
  • 为了研究从纳米颗粒中释放的Resolvin E1 (RvE1) 的免疫调节作用.
  • 评估系统在合金植入物周围减少纤维化的有效性.

主要方法:

  • 开发出了多样性 (乳酸-co-glycolide) 和Eudragit S100 (PLGA-ES100) 的纳米粒子.
  • 工程纳米粒子在性条件下降解,以便按需RvE1释放.
  • 在老鼠皮下模型中植入了AZ31合金的纳米颗粒.

主要成果:

  • 在性条件下,PLGA-ES100纳米粒子特别释放RvE1.
  • 纳米颗粒促进了M2巨细胞的两极分化,并抑制了促炎性细胞因子 (TNF-α,IL-1β).
  • 在体内植入显示显著减少纤维化囊厚度和增加CD163表达.

结论:

  • 响应pH的纳米颗粒提供了一个局部的策略,通过植入物降解触发的,解决炎症的药物释放.
  • PLGA-ES100-RvE1系统提供了一个模块化平台,用于控制可生物吸收的植入物接口上的免疫反应.
  • 这种方法通过调节当地的免疫环境来提高可生物降解植入物的生物相容性.