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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
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临床表现 临床表现

Abbie Palmer1, Millie Sander1, Clive G Ballard1

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长期的Covid可能会导致显著的认知障碍,特别是影响记忆力和执行功能. 生活方式因素与这些缺陷有关,强调需要有针对性的临床指导.

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科学领域:

  • 神经科学是一个神经科学.
  • 公共卫生 公共卫生
  • 认知科学 认知科学

背景情况:

  • 长期Covid影响至少9.9%的个人,神经精神症状如认知障碍影响超过25%的患者.
  • 长期Covid的认知缺陷显著损害生活质量,就业和社会活动.
  • 长期Covid认知症状的病因不明,需要进一步研究.

研究的目的:

  • 描述长期Covid患者的认知特征.
  • 将长期Covid患者的认知表现与健康,年龄相匹配的队列进行比较.
  • 为了确定与长期Covid认知障碍相关的因素.

主要方法:

  • 在COVID-19后招募了2185名具有主观认知障碍的参与者参加BEACON试验.
  • 管理的人口统计,健康,心理健康,疲劳和福祉问卷.
  • 利用FLAME认知测试系统进行记忆,注意力和执行功能评估;与PROTECT-UK队列数据进行比较分析.

主要成果:

  • 与健康对照人群相比,BEACON队列表现出独特的认知障碍特征.
  • 观察到显著的记忆力和执行功能受损,特别是在那些有严重的Covid-19病史的人群中.
  • 回归分析确定了生活方式因素和认知障碍之间的关联.

结论:

  • 提供了长期Covid患者的详细认知特征,揭示了潜在的独特认知轨迹.
  • 强调临床指导对于检测,监测和治疗长期Covid中的认知障碍的重要性.
  • 强调需要进一步研究长期Covid认知功能障碍的潜在机制和有效干预措施.