生物标志物 生物标志物
Lianlian Du1,2, Konstantinos Arfanakis1,3, Arnold M Evia1
1Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
大脑动脉样硬化 (ARTS) 的发病发生在93岁左右,女性和黑人/拉丁裔个体的发病时间较早. 在男性和患有混合病理的人群中,进展速度更快.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 老年学是一门学科.
背景情况:
- 大脑动脉硬化是大脑小血管疾病的关键因素,影响认知和痴呆风险.
- 目前诊断死后,有必要使用体内诊断方法.
- 以前的研究开发了一种基于MRI的动脉样硬化分类器,称为ARTS.
研究的目的:
- 用ARTS分类器估计大脑动脉样硬化的发病年龄.
- 了解动脉样硬化的纵向进展.
- 调查影响非痴呆症患者发病和进展的因素.
主要方法:
- 利用了来自五项研究的1,195名没有痴呆症的参与者的MRI数据.
- 应用高斯混合模型 (GMM) 来识别高和低的ARTS分数组.
- 采用采样代局部近似 (SILA) 来建模ARTS积累轨迹,并分析了人口统计和病理的发病差异.
主要成果:
- 确定了动脉样硬化病的平均发病年龄为93岁.
- 与男性和白人参与者相比,女性和黑人/拉丁裔参与者表现得更早.
- 男人,黑人参与者,以及患有并存病理 (动脉样硬化,心脏病发作) 的参与者表现出更快的ARTS积累.
结论:
- 大脑动脉样硬化的发病和进展因性别和种族/种族而异.
- 同时发生的病理加速动脉样硬化进展,突出显示混合脑血管疾病的影响.
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