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临床表现 临床表现

Gonzalo Sánchez-Benavides1,2,3, Mariateresa Buongiorno4, Michalis Kassinopoulos1

  • 1Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.

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概括
此摘要是机器生成的。

在没有认知障碍的个体中,嗅觉功能障碍 (OD) 与减少的淋巴功能有关,通过DTI-ALPS测量. 这种关联表明OD可能表明早期的淋巴系统损伤,即使有正常的嗅觉功能.

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科学领域:

  • 神经科学是一个神经科学.
  • 医疗成像医学成像
  • 老年学是指老年学的学科.

背景情况:

  • 嗅觉功能障碍 (OD) 在衰老和神经退行性疾病中很普遍.
  • 缺陷的淋巴功能可能会导致蛋白质聚合物在嗅觉系统中的积累.
  • 这项研究研究了与痴呆症风险较高的人群中嗅觉相关的淋巴功能.

研究的目的:

  • 探索嗅觉表现和淋巴功能 (DTI-ALPS) 之间的关联,在具有痴呆症家族病史的认知正常个体中.
  • 评估是否可以检测到减少的淋巴功能,即使在正常的嗅觉性能范围内.

主要方法:

  • 分析了来自ALFA队列的1369名参与者 (年龄在47-77岁之间).
  • 使用嗅探棒识别 (SSI) 测试评估的嗅觉;OD定义为SSI <12.
  • 通过沿周血管空间 (DTI-ALPS) 进行扩散张力成像测量淋巴功能.
  • 后勤回归和通用线性模型 (GLM) 用于分析关联,控制年龄,教育,性别和APOE-ɛ4状态.

主要成果:

  • 嗅觉功能障碍 (18.8%) 与年龄较大,男性性别和较低的DTI-ALPS分数 (p=0.04) 有关.
  • 较低的DTI-ALPS得分与持续的SSI得分 (p=0.007) 有积极关联,特别是在没有OD的个体中 (p=0.02).
  • 趋势表明OD患者的淋巴功能下降,尽管在分层分析中并不总是统计学上显著.

结论:

  • 具有较低嗅觉识别分数的认知能力正常的个体表现出减少的淋巴功能 (DTI-ALPS).
  • 嗅觉和淋巴功能之间的这种联系甚至存在于正常的嗅觉范围.
  • 在有认知能力下降风险的个体中,OD可能是淋巴功能障碍的潜在早期临床标志物.