临床表现 临床表现
Nav Vij1, Jermyn Z See1, See Ann Soo1
1Neurowyzr Pte Ltd, Singapore, Singapore, Singapore.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
通过数字查,轻度认知障碍 (MCI) 的早期检测是可能的. 改变生活方式,如炼和控制糖尿病,可以显著降低MCI风险和痴呆成本.
科学领域:
- 神经学 神经学
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 轻度认知障碍 (MCI) 是正常衰老和痴呆症之间的关键阶段,为早期干预提供了机会.
- 痴呆症对全球经济造成重大负担,预计到2030年,该疾病的成本将超过2万亿美元.
- 在新加坡,痴呆症影响大约10%的老年人,导致大量的医疗保健费用.
研究的目的:
- 评估Neurowyzr的数字大脑功能屏幕 (DBFS) 在识别MCI早期迹象方面的有效性.
- 在新加坡人口中确定与MCI相关的可修改的生活方式风险因素.
- 探索数字工具对于早期MCI检测和预防策略的潜力.
主要方法:
- 医疗级数字工具DBFS评估了注意力,执行功能,即时记忆和工作记忆的认知功能.
- 一个生活方式问卷收集了有关身体活动,睡眠,营养,物质使用,医疗状况和认知刺激的数据.
- 统计建模应用于新加坡对2000多名被查的人的真实数据,以确定MCI风险因素.
主要成果:
- 认知功能随着年龄的增长而下降,糖尿病,吸烟和高糖摄入量被确定为重要的MCI风险因素.
- 定期的体育活动,特别是心血管和抵抗训练,显示出神经保护作用.
- 更高的教育水平和参与认知刺激活动与认知衰退的可能性降低有关.
结论:
- 现实数据证实了MCI的多因素性质,并突出了关键可修改的风险因素.
- DBFS是一个有前途的可扩展工具,用于早期MCI检测,并促进有针对性的预防.
- 侧重于糖尿病管理,戒烟,减少糖摄入,运动,教育和认知刺激的干预措施可以减轻MCI风险并减少痴呆症的经济影响.
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