Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Preclinical Development: Overview01:28

Preclinical Development: Overview

5.7K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
5.7K
Clinical Trials: Overview01:11

Clinical Trials: Overview

4.5K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.5K
Drug Discovery: Overview01:26

Drug Discovery: Overview

10.9K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
10.9K
Drug Administration and Therapy Phases: Overview01:26

Drug Administration and Therapy Phases: Overview

1.1K
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
1.1K
In Vitro Drug Release Testing: Overview, Development and Validation01:10

In Vitro Drug Release Testing: Overview, Development and Validation

269
In vitro dissolution and drug release tests assess how quickly and how much of a drug is released from its dosage form into an aqueous medium under standardized laboratory conditions. These tests are essential tools in pharmaceutical development and quality assurance, offering insight into the drug's performance before clinical use.During formulation development, dissolution testing identifies incomplete or inconsistent drug release issues. It also supports decisions on selecting the optimal...
269
Drug Regulation01:25

Drug Regulation

2.7K
Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
2.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Soluble Urokinase Plasminogen Activator Receptor Primes Macrophages and Worsens Heart Failure with Preserved Ejection Fraction.

bioRxiv : the preprint server for biology·2026
Same author

Rare Complications in Crohn's Disease: Diagnostic and Therapeutic Challenge of Dermal Abscesses Caused by Nontuberculous Mycobacteria Following Infliximab Therapy, and Fluoroquinolone-Related Achilles Tendon Rupture.

The American journal of case reports·2026
Same author

Optimising a behavioural intervention to support endocrine therapy adherence for women with breast cancer: protocol for the ROSETA optimisation factorial randomised controlled trial.

Trials·2026
Same author

Sample validity lessons learned from challenging cases and proposed biomarkers for synthetic urine detection.

Journal of analytical toxicology·2026
Same author

Ketogenic Diet and Exercise Improve Peripheral Neuropathy in a Mouse Model of Metabolic Syndrome.

Diabetes·2026
Same author

Complosome Activation after Myocardial Infarction in a Murine Model of Permanent LAD Ligation.

Stem cell reviews and reports·2025

相关实验视频

Updated: Jan 7, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

10.1K

药物开发 药物开发

Sarah E Elzinga1, Diana M Rigan2, Crystal Pacut2

  • 1Michigan State University, East Lansing, MI, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
概括
此摘要是机器生成的。

双重SGLT1/2抑制剂索塔格利弗洛辛在有或没有代谢压力的小鼠中改善了代谢健康. 然而,认知效益仅在健康对照组中观察到,这表明代谢压力中的认知障碍可能与葡萄糖无关.

更多相关视频

In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing
08:04

In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing

Published on: May 11, 2021

3.3K
Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells
05:45

Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells

Published on: October 10, 2025

446

相关实验视频

Last Updated: Jan 7, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

10.1K
In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing
08:04

In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing

Published on: May 11, 2021

3.3K
Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells
05:45

Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells

Published on: October 10, 2025

446

科学领域:

  • 神经科学是一个神经科学.
  • 代谢科学 代谢科学
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 代谢性压力 (肥胖,糖尿病前期,糖尿病) 的增加增加了痴呆症的风险,特别是阿尔茨海默病和相关痴呆症 (AD/ADRD).
  • 针对中年代谢性压力提供了一种潜在的策略,以防止晚年认知能力下降.
  • -葡萄糖共运输体 (SGLT) 抑制剂对代谢状况有希望,并可能有利于大脑健康,但它们对认知的特定影响,特别是双重SGLT1/2抑制,需要进一步研究.

研究的目的:

  • 研究SGLT1和SGLT2双抑制剂索塔格利弗洛辛 (SOTA) 对代谢压力的小鼠模型中的认知功能和代谢健康的影响.
  • 为了确定SOTA治疗是否可以减轻与饮食诱导的代谢功能障碍相关的认知缺陷.
  • 探索SOTA管理后代谢改善和认知结果之间的关系.

主要方法:

  • 在男性C57BL/6小鼠中使用高脂肪饮食 (HFD) 和L-Nitro_L-arginine methylester诱导代谢压力.
  • 小鼠每天接受10周的索塔格利弗洛辛 (SOTA; 30 mg/kg) 或载体的口服测量.
  • 使用拼图盒和莫里斯水迷宫测试评估认知功能;分析了代谢参数 (体重,葡萄糖耐受性,HbA1c) 和血细胞因子.

主要成果:

  • 在HFD和对照小鼠中,SOTA治疗显著降低了体重,改善了葡萄糖耐受性,降低了HbA1c水平.
  • 在HFD小鼠中,血CCL-2细胞因子水平升高被SOTA治疗降低.
  • 虽然HFD损害了认知结果,但SOTA在对照小鼠中改善了执行功能,但没有影响HFD小鼠的认知表现.

结论:

  • 索塔格利弗洛辛有效地改善了新陈代谢参数,而不考虑饮食引起的压力.
  • 只有在非压力对照小鼠中观察到认知改善,这表明代谢压力诱导的认知障碍可能不仅仅取决于葡萄糖水平.
  • 这些发现凸显了SGLT抑制在代谢压力背景下的代谢和认知益处之间的潜在分离.