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临床表现 临床表现

Taiane Santos Garcia1, Sheyla Velasques Paladini1, João Pedro Ferrari-Souza2

  • 1Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.

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概括
此摘要是机器生成的。

糖尿病老年人使用的潜在不合适药物 (PIM) 可能会影响认知功能和阿尔茨海默病 (AD) 生物标志物. 这凸显了需要谨慎的处方,以避免误诊,并确保患者的安全.

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科学领域:

  • 神经科学是一个神经科学.
  • 老年病的医生 老年病的医生
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 阿尔茨海默病神经成像计划 (ADNI) 的数据用于改善阿尔茨海默病 (AD) 临床试验.
  • 糖尿病患者经常使用可能不合适的药物 (PIMs),这些药物可能会影响认知和AD生物标志物.
  • 在糖尿病患者中使用PIM可能会混AD诊断.

研究的目的:

  • 研究糖尿病患者使用PIM与认知变化之间的关联.
  • 检查PIM使用与生物标志物之间的联系,这些生物标志物可能被误解为AD.

主要方法:

  • 使用的ADNI数据包括药物史,糖尿病状况,认知表现和生物标志物 (PET/MRI,β-粉样蛋白,tau).
  • 使用Beers标准对患有糖尿病的老年人进行识别的PIM.
  • 从ADNI数据库中分析了ADNI诊断的和没有AD的个体的数据.

主要成果:

  • 该研究包括411人 (310人患有糖尿病),其中96人被确定为PIM用户.
  • 常见的PIM包括硫尿素和短或快速起作用的胰岛素.
  • 这些药物可能会导致低血糖症,导致老年人感到困惑,兴奋和认知变化.

结论:

  • 糖尿病老年人通常使用PIM,可能会影响认知结果和AD生物标志物.
  • 合理的处方对于这个弱势群体至关重要.
  • 这项研究有助于差异诊断,并促进糖尿病老年人更安全的药物治疗.