生物标志物 生物标志物
Cassandra DeMarshall1, Jeffrey Viviano1, Anuradha Krishnan1
1Durin Life Sciences, Stratford, NJ, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
Duritect-ADTM 血液检测准确地使用自身抗体生物标志物检测阿尔茨海默病 (AD) 病理. 该测试有助于识别患有阿尔茨海默病风险的个体,从早期到晚期.
科学领域:
- 神经学 神经学
- 生物标志物发现发现
- 诊断测试 诊断测试 诊断测试
背景情况:
- 阿尔茨海默病 (AD) 构成了重大挑战,需要早期检测方法.
- 当前的诊断方法可能无法在最早的临床前阶段识别AD病理.
- 基于血液的生物标志物为AD评估提供了最少侵入性的替代方案.
研究的目的:
- 评估Duritect-ADTM测试对检测AD相关病理过程的临床实用性.
- 评估该测试能够识别患有阿尔茨海默病风险的个体在其临床谱中,包括前期阶段.
- 为了确定专有风险评分是否可以预测未来的AD发展.
主要方法:
- 从阿尔茨海默病神经成像倡议 (ADNI) 队列中选了509个血清样本,包括症状前,先发性 (MCI) 和轻度中度AD的个体,以及健康的对照.
- 使用了针对AD病理学特有的自抗体生物标志物的定制面板.
- 应用了一种专有机器学习算法来计算每个样本的阿尔茨海默病风险评分 (ADRS).
主要成果:
- 通过ADRS,Duritect-ADTM测试通过90%以上的准确度将ADNI受试者与对照者区分开来.
- 该测试在识别AD相关病理方面表现出高灵敏度和特异性.
- 自体抗体生物标志物小组有效识别了正在进行的AD病理的个体.
结论:
- Duritect-ADTM是一种CLIA/CAP验证的,基于血液的自身抗体测试,用于评估55岁以上具有认知障碍症状的AD患者的AD风险.
- 该测试是准确的,最少的侵入性,并且具有成本效益,可帮助早期检测AD病理.
- Duritect-ADTM支持识别早期的AD相关病理在前期 (MCI) 和AD的后期阶段.
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