生物标志物 生物标志物
Arno Liseune1, Ricardo Magalhães1, Simon Van Eyndhoven1
1Icometrix, Leuven, Belgium.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
针对ARIA检测和分级的自动化软件显示了专家级别的协议. 使用该工具协助放射科医生显著提高了他们对ARIA严重程度的分级能力,帮助治疗决策.
科学领域:
- 神经辐射学神经辐射学
- 医疗成像中的人工智能
- 阿尔茨海默病的治疗方法 治疗方法
背景情况:
- 针对β粉样蛋白的单克隆抗体疗法可以导致ARIA-E () 和ARIA-H (微出血,表面 siderosis).
- 对临床医生来说,准确地识别和分级ARIA的严重程度是具有挑战性的,影响治疗决策.
- 辅助自动检测和分级软件可以增强ARIA的放射性评估.
研究的目的:
- 评估ICOBrain ARIA的性能,这是一个FDA批准的软件,用于ARIA-E和ARIA-H的自动检测和严重程度分级.
- 为了比较软件和非专家放射科医生 (辅助和无辅助) 与专家神经放射科医生在分级ARIA严重性的协议.
主要方法:
- 16名非专家放射科医生评估了199名阿尔茨海默病患者用阿杜卡努马布治疗的病例,两次:辅助和无辅助的ICOBrain ARIA.
- 基础真相 ARIA严重程度是由三个专家神经放射学家为ARIA-E,ARIA-H微出血 (MH) 和ARIA-H表面 siderosis (SS) 建立的.
- 使用Obuchowski协议度量来比较软件,无助读者和辅助读者与专家的地面真相.
主要成果:
- ICOBrain ARIA的自动化严重性评级证明了与专家评级的可互换性,实现了与专家间协议相比的协议水平.
- 与ARIA-E,ARIA-H MH和ARIA-H SS.的无助读数相比,辅助放射科医生与专家的可互换性显著改善 (p<0.05).
- 软件的协议指标分别为0.853 (ARIA-E),0.805 (ARIA-H MH) 和0.745 (ARIA-H SS),而辅助阅读器则从0.78,0.75,0.66提高到0.83,0.78,0.72分别.
结论:
- 独立的ICOBrain ARIA软件提供了与专家神经放射学家可比的严重程度分级.
- 使用ICOBrain ARIA作为辅助工具显著提高了放射科医生对ARIA严重程度的分级能力,从而与专家评估更好地互换.
- 这种辅助技术有望提高ARIA评估在临床实践中的一致性和准确性.
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