痴呆症护理研究和心理社会因素
1University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
移动阿尔茨海默氏病研究和评估 (MADRE) 研究成功招募并保留了黑人/非洲裔美国人参与者进行家庭阿尔茨海默氏病和阿尔茨海默氏病相关痴呆症评估. 这凸显了为服务不足的人群提供可访问的,以社区为基础的研究的有效性.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 阿尔茨海默病 (AD) 和与阿尔茨海默病相关的痴呆症 (ADRD) 不成比例地影响西班牙裔/拉丁裔 (H/L) 和黑人/非洲裔美国人 (B/AA) 人口.
- 这些群体在临床研究中的代表性不足在早期发现和监测ADRD方面造成了关键的知识差距.
- 数据有限阻碍了对生物标志物及其对不同人群认知的影响的评估.
研究的目的:
- 解决B/AA和H/L人口在AD/ADRD研究中的不足.
- 实施可访问的,以社区为基础的评估,以改善参与者参与和数据收集.
- 为了促进AD/ADRD研究的B/AA老年人的深度表型.
主要方法:
- 移动阿尔茨海默氏病研究和评估 (MADRE) 研究在家庭或社区中心进行了评估.
- 针对B/AA和H/L人群的有针对性的招聘和保留策略.
- 收集血液样本用于血生物标志物分析,并收集人口和认知数据.
主要成果:
- 在18个月内成功招募了159名B/AA参与者,年度保留率超过93%.
- 该队列包括各种认知状态:33%的轻度认知障碍 (MCI),30%的非MCI受损,34%的认知不受损 (CU).
- 分析包括血生物标志物,APOE ε4等位基因状态和认知评估 (平均MMSE 27.18).
结论:
- 这项MADRE研究证明了使用可访问的家庭评估方法招募和留住B / AA参与者的可行性和成功.
- 具有文化相关性和方便的研究方法是有效的,以吸引服务不足的人群参与AD/ADRD研究.
- 这个倡议为了解AD/ADRD在代表性不足的社区提供了有价值的数据.
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