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临床表现 临床表现

Matin Soeizi1,2, Tovia Jacobs1, Zafarullah M Chaudhary1,2

  • 1NYU Grossman School of Medicine, New York, NY, USA.

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概括
此摘要是机器生成的。

痴呆症中的神经精神症状 (NPS) 通常与阿尔茨海默氏症痴呆症 (ADD) 病理学有关. 然而,在Lewy体痴呆症 (LBD),前性痴呆症 (FTD) 和血管痴呆症中,NPS可能会被错误地归因于NPS,从而影响准确的诊断.

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科学领域:

  • 神经学 神经学
  • 神经科学是一个神经科学.
  • 老年病的医生 老年病的医生

背景情况:

  • 神经精神症状 (NPS) 显著损害痴呆症患者和照顾者的生活质量.
  • 通过神经精神病 inventory问卷 (NPI-Q) 评估的高NPS负担与勒维体痴呆症 (LBD) 和阿尔茨海默病痴呆症 (ADD) 有关.
  • 精确诊断痴呆症亚型具有挑战性,特别是当NPS复杂化临床表现时.

研究的目的:

  • 将痴呆症的临床诊断与神经病理学发现进行比较.
  • 在NPS的存在下,评估痴呆症亚型的诊断准确性.
  • 调查NPS与特定痴呆病理之间的关联.

主要方法:

  • 使用国家阿尔茨海默氏症协调中心 (NACC) 数据进行的回顾性纵向队列研究.
  • 纳入标准:在轻度认知障碍或轻度痴呆阶段患有妄想,幻觉或兴奋 (NPI-Q) 的参与者.
  • 排除标准:精神分裂症和未指明的精神疾病. 临床诊断与神经病理一致性的分析,使用R软件和ANOVA.

主要成果:

  • 包括1,089名参与者;NPS的平均年龄为77.96岁.
  • 880名参与者报告了兴奋 (NPI-Q),296名参与者报告了妄想,184名参与者报告了幻觉.
  • 对ADD的一致性很高 (94%),但对于前性痴呆症 (FTD) (36%) 和勒维体痴呆症 (LBD) (48.2%) 的一致性较低. 在FTD,LBD和血管痴呆病例中,NPS的显著错误归因,通常是ADD.

结论:

  • NPS主要与阿尔茨海默氏症痴呆症 (ADD) 病理学有关.
  • 超过50%的确诊LBD,FTD或血管痴呆病理的病例显示NPS错误地归因于其他诊断.
  • 需要进一步的研究,以提高与行为障碍相关的痴呆症的诊断准确度.