生物标志物 生物标志物
James E Galvin1, Tulimalefo'i Vaofanua2, Grace Grace Tuato'o2
1University of Miami Miller School of Medicine, Boca Raton, FL, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
阿尔茨海默病 (AD) 和相关的痴呆症 (ADRD) 影响了美国萨摩亚31%的萨摩亚老人. 大多数认知障碍病例与AD病理学无关,这表明需要进行非AD生物标志物研究.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 公共卫生 公共卫生
背景情况:
- 普伊·马卢·马纳图研究调查了美国萨摩亚的阿尔茨海默病和相关痴呆症 (ADRD) 患病率,风险因素和生物标志物概况.
- 本报告详细介绍了NIA资助的这项正在进行的研究的最初400名参与者的认知和生物标志物发现.
研究的目的:
- 为了确定50岁及以上的萨摩亚老年人中ADRD的患病率.
- 确定风险和弹性因素,并探索与认知衰退相关的遗传和血液生物标志物.
- 在这个人群中评估健康素养和认知查工具.
主要方法:
- 981名萨摩亚长老 (50岁以上) 的概率样本将使用UDSv3.0.0.进行金标准评估.
- 将探索包括PrecivityAD2在内的遗传和血液生物标志物.
- 认知功能将使用MoCA,Cognivue Clarity,QDRS和CDR-SB进行评估.
主要成果:
- 队列 (平均年龄为60.4岁) 显示显著的认知障碍,其中31%的CDR-SB.得分为0.5+
- 认知障碍患者年龄较大,男性,并发病率较高,MoCA分数较低.
- ApoE ε4不是一个重要的风险因素,AD生物标志物 (Aβ42/40,pTau217) 在认知障碍组之间没有差异.
结论:
- 认知障碍影响了美国萨摩亚31%的萨摩亚老人,大多数病例与AD病理学无关.
- 在这个人群中,ApoE ε4似乎不是认知障碍的主要危险因素.
- 进一步的研究应该探索非痴呆症生物标志物,文化定制的认知评估,以及个体内变化测量 (CDR) 对痴呆症检测的有用性.
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