临床表现 临床表现
Abdul Moeed1, Hassan Waseem2, Abdul Hannan Siddiqui1
1Dow Medical College, Dow University of Health Sciences, Karachi, Karachi, Sindh, Pakistan.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
益生菌显著改善阿尔茨海默病 (AD) 患者的认知功能,通过增强抗氧化剂,如谷氨,并减少氧化应激标志物,如malondialdehyde.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 阿尔茨海默病 (AD) 是一种进展性神经认知障碍,影响全球5000万人.
- 阿尔茨海默病约占所有痴呆病例的70%.
- 目前针对阿尔茨海默病的治疗方法的疗效有限.
研究的目的:
- 分析益生菌对AD患者神经认知功能的影响.
- 评估益生菌对AD炎症和氧化应激标志物的影响.
- 为AD管理提供基于证据的关于益生菌补充剂的见解.
主要方法:
- 在PubMed,Cochrane Central和Google Scholar进行了系统的文献搜索,截至2025年1月.
- 来自五项随机临床试验的数据被定量分析,涉及219名阿尔茨海默病患者.
- 审查经理5.4被用于统计分析,采用随机效应模型.
主要成果:
- 益生菌补充剂显著改善了AD患者的迷你精神状态检查得分 (MD = 2.49,p = 0.02).
- 益生菌增加了谷氨水平 (MD = 17.78 μmol/L,p = 0.02) 和降低了甲水平 (MD = -1.54 μmol/L,p < 0.0001).
- 这些发现表明,使用益生菌可以减少氧化应激和炎症.
结论:
- 益生菌在改善阿尔茨海默病患者的神经认知功能方面表现出有效性.
- 益生菌补充剂对氧化应激和炎症的关键标志物产生积极影响.
- 这些结果支持益生菌作为AD的辅助疗法的潜力.
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