临床表现 临床表现
Kevin Duff1,2, Jace B King3, John M Hoffman4
1Oregon Health & Science University, Portland, OR, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
短期实践效应 (STPE) 可能表明主观认知衰退 (SCD) 个体的阿尔茨海默病 (AD) 生物标志物阳性. 这一发现可能有助于丰富阿尔茨海默病的临床试验.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物 生物标志物
- 阿尔茨海默氏症疾病研究研究
背景情况:
- 主观认知衰退 (SCD) 可能是临床前阿尔茨海默病 (AD) 的早期迹象.
- 患有SCD的个体是一个多样化的群体,具有各种潜在原因.
- 之前的研究探讨了轻度认知障碍 (MCI) 和AD的短期实践效应 (STPE).
研究的目的:
- 调查STPE是否与阿尔茨海默病 (AD) 生物标志物有关.
- 为了确定STPE是否能够区分有或没有认知投诉的个体.
主要方法:
- 75名认知正常的参与者被分为SCD (n=11) 和认知正常 (CN,n=64) 组.
- 参与者在一周内两次完成认知电池,以评估STPE.
- 生物标志物分析包括APOE基因定型,海马体体积的MRI和粉样蛋白PET扫描.
主要成果:
- 在SCD个体中,更多的APOE ε4等位基因与较小的STPE相关 (r=-.42).
- 较大的海马体积与较大的STPE相关 (r=0.25).
- 73%的SCD参与者是粉样蛋白阳性,而CN参与者是19% (p < 0.001).
结论:
- 在SCD患者中,STPE与AD生物标志物有关,反映了MCI和AD的发现.
- 在SCD中,STPE可以作为生物标志物阳性的指标.
- STPE可能是一个具有成本效益的工具,可以丰富AD临床试验.
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