生物标志物 生物标志物
Jiaqi Wen1,2, Zifei Liang1, Chenyang Li3
1New York University Grossman School of Medicine, New York, NY, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
衰老会损害运动和认知功能. 先进的MRI显示了运动皮层 (MC) 和MC-striatum通道的退化,与认知能力下降和潜在的早期痴呆症标志物有关.
科学领域:
- 神经科学是一个神经科学.
- 衰老研究研究 衰老研究
- 医疗成像医学成像
背景情况:
- 认知和运动功能的下降是衰老的一个关键方面.
- 运动皮质 (MC) 和其外投,包括皮质脊髓管 (CST) 和MC-striatum管,对于运动控制和潜在的认知功能至关重要.
- 了解这些神经通路的与年龄相关的退化对于了解认知衰退至关重要.
研究的目的:
- 为了研究运动皮质 (MC),皮质脊髓 (CST) 和MC-striatum管道在衰老中的综合性退化.
- 利用先进的MRI技术,探索成年人一生中认知衰退背后的神经机制.
- 在这些特定的神经通路中识别与衰老相关的结构和功能变化.
主要方法:
- 在使用T1-MPRAGE,T2-SPACE,pCASL和扩散MRI序列的HCP-Aging数据集中分析了339名右撇子受试者.
- 处理结构指标 (体积,曲率) 和生成脑血流 (CBF) /动脉过路时间 (ATT) 地图.
- CST和MC-striatum通道的通道图,与跨年龄组的沿通道分数异质性 (FA) 比较.
主要成果:
- 年长的成年人 (65-90岁) 与年轻的成年人 (36-65岁) 相比,他们的认知得分较低.
- 衰老与减少的MC体积,减少的CBF,增加的T1/T2比率,增加的平均皮层曲率和延长的ATT相关.
- 在老年人中,在CST和MC-striatum通道中观察到减少的FA,FA与MC体积积极相关,与ATT和曲率负相关. MC-状体管 FA 与认知得分相关.
结论:
- 衰老涉及MC的结构和功能下降,包括降低白质完整性在CST和MC-striatum通道.
- 肌肉条管的退化与衰老中的认知衰退有关,并与肌肉条管损伤有关.
- 研究结果表明,这些路径的早期变化可能表明与年龄相关的痴呆症,并有助于差异诊断.
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