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临床表现 临床表现

Sarah Prieto1,2, Molly Split1, Alyssa N De Vito3,4

  • 1Alpert Medical School of Brown University, Providence, RI, USA.

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概括
此摘要是机器生成的。

每天的压力波动会影响老年人的认知表现. 较高的压力改善了视觉工作记忆,特别是在粉样β阳性个体中,同时减缓了处理速度.

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科学领域:

  • 认知神经科学是一种认知神经科学.
  • 老年学是指老年学的学科.
  • 心理学 心理学 心理学

背景情况:

  • 传统的研究将老年人中的压力与认知功能障碍联系在一起,使用跨组比较.
  • 基于智能手机的评估使得可以对压力和认知进行个人内可变性分析.
  • 粉样蛋白-β (Aβ) 状态可能会影响压力-认知关系.

研究的目的:

  • 调查压力在人体内的变化,作为认知结果的预测因素.
  • 为了检查压力认知关联如何根据粉样β (Aβ) 状态不同.

主要方法:

  • 123名认知正常的成年人 (60-81岁) 在8天内完成了每天基于智能手机的认知任务 (处理速度,视觉工作记忆,情节性记忆).
  • 参与者在每次认知评估前立即通过M2C2应用报告了压力水平.
  • 多层次建模分析了人体内压力和会议数量之间的相互作用,通过Aβ PET成像结果分层的探索性分析.

主要成果:

  • 较低的压力与随着时间的推移更快的处理速度 (PS) 相关 (p=.01).
  • 较高的压力与会话数和视觉工作记忆 (WM) 准确度 (p=.04) 之间的更明显的积极关联有关.
  • 在粉样β阳性 (Aβ+) 个体中,较高的压力与会话数量相互作用,改善了WM准确性 (p=.02).

结论:

  • 个人内压力波动在远程监控期间显著影响认知表现.
  • 增加的压力可能会影响处理速度,但会增强视觉工作记忆,特别是在Aβ+个体中.
  • 压力引起的注意力资源变化可能解释特定领域的认知性能变化.