临床表现 临床表现
Andrew J Petkus1, Bryan Rowe2, Lucy Montoya1
1University of Southern California, Los Angeles, CA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
听力和运动技能下降与患有阿尔茨海默病 (AD) 或有风险的拉丁裔人的记忆力和执行功能较差有关. 这些发现突出了AD神经病理学的潜在早期指标.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 遗传学 是一个遗传学.
背景情况:
- 运动和感官衰退是阿尔茨海默病 (AD) 的危险因素.
- 运动/感官能力和认知之间的关联在拉丁裔人口和自体主导AD (ADAD) 中缺乏研究.
- ADAD提供了一个独特的模型,因为与晚发性AD (LOAD) 相比,混因素较少.
研究的目的:
- 检查运动能力,听力和嗅觉与情节性记忆和执行功能之间的关联.
- 为了调查这些协会的异质性,在风险ADAD或LOAD的拉丁裔样本中占主导地位.
- 探索临床组对这些关系的缓解作用.
主要方法:
- 对83名拉丁裔使用NIH工具箱运动,感觉和认知电池进行横截面研究.
- 参与者分为ADAD突变携带者,非携带者风险和LOAD风险/受影响的个人.
- 调整为年龄,性别和教育的多变量线性回归,根据临床组检查效果适度.
主要成果:
- 较差的板性能,握力和听力与所有参与者的记忆力,认知灵活性和抑制性差有关.
- 平衡和嗅觉也与灵活性和抑制相关.
- 与其他群体相比,听力缺陷与ADAD突变载体的灵活性和抑制的关联明显更大.
结论:
- 听力较差,精细运动技能和上肢力量与拉丁裔ADAD或LOAD风险的记忆力和执行功能下降相关.
- 阿尔茨海默病的神经病理可能会影响运动技能和听觉处理.
- 这些发现表明,在有风险的人群中,阿尔茨海默病的潜在早期生物标志物.
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