生物标志物 生物标志物
Yingxu Liu1, Kirsten M Lynch1, Pranali Khobragade2
1Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
表面白质变化,特别是更高的细胞内体积分数 (FICVF),预测老年人轻度认知障碍 (MCI) 的风险较低. 这种关系在具有不利社会经济背景的个体中更为强烈,突出显示FICVF是关键生物标志物.
科学领域:
- 神经成像是一种神经成像.
- 老年学是一门学科.
- 认知科学 认知科学
背景情况:
- 表面白质微观结构的变化可能会先于灰质缩和认知障碍.
- 了解这些变化在老年,非西方人口和社会经济层面的理解是有限的.
研究的目的:
- 调查老年印度成年人白质微观结构和轻度认知障碍 (MCI) 之间的关系.
- 检查社会经济因素是否会改变微观结构与认知的关系.
主要方法:
- 在印度长度衰老研究 - 痴呆症诊断评估 (LASI-DAD) 中,利用了193名老年人的多扩散MRI.
- 从白质中获得的神经元导向分散和密度成像 (NODDI) 度量,包括细胞内体积分数 (FICVF).
- 评估了区域/全球NODDI指标与MCI之间的关联,检查了与识字,教育,就业和社区环境的相互作用.
主要成果:
- 较高的FICVF与较低的MCI风险相关,显示出比其他NODDI指标和宏观结构措施更大的敏感性.
- 读写能力显著改变了FICVF-认知关系,在社会经济背景不利的人群中观察到更强的关联.
- 在教育,就业和社区环境中也发现了类似的,尽管不显著的互动趋势.
结论:
- 由FICVF指出的神经质密度是社区人口认知结果的有价值预测指标.
- 在具有不利社会经济背景的个人中观察到FICVF和降低MCI风险之间的更强的关联.
- 这些发现强调了微观结构完整性及其在不同社会经济群体之间的差异性影响的重要性.
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