生物标志物 生物标志物
Nolan K Meyer1, Robert I Reid1, Michael G Kamykowski1
1Mayo Clinic, Rochester, MN, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
扩散核磁共振 (MRI) 协议的标准化将扫描器差异最大限度地降低,减少在多地点的衰老和痴呆症研究中数据协调的需要. 这样可以确保在不同研究地点进行更可靠的生物标志物分析.
科学领域:
- 神经成像是一种神经成像.
- 生物标志物 生物标志物
- 衰老和痴呆症研究研究
背景情况:
- 在多中心研究中,扩散MRI (dMRI) 对衰老和痴呆症生物标志物至关重要.
- 扫描器间的变化 (供应商,硬件,算法) 可以在dMRI测量中引入系统差异.
- 协调通常是必要的,但可能会降低数据对生理因素的敏感性.
研究的目的:
- 测试协议标准化是否能最大限度地减少dMRI测量中的机器起源差异.
- 评估标准化是否消除了获得后协调的需要.
- 为了比较DTI和NODDI关于网站敏感性的措施.
主要方法:
- 分析了GE和西门子扫描仪上的交叉数据 (80名参与者),使用不同的协议.
- 通过使用标准化协议,从两个地点分析了梅奥诊所衰老研究 (MCSA) 的纵向数据.
- 使用组图密度和体基因 (GCC) 测量方法进行dMRI指标 (MD,FA,NODDI) 的比较.
主要成果:
- 协议调整 (重新采样,共享b) 减少了交叉数据的分布差异.
- 标准化的MCSA数据显示了对齐的dMRI密度,在各站点之间没有显著的GCC-FA或GCC-MD差异.
- 在NODDI测量中,与DTI测量相比,与地点相关的不一致性更大.
结论:
- 协议和处理标准化有效地减少dMRI中的机器起源差异.
- 标准化减少了获得后协调的需要,保持了数据的敏感性.
- 与NODDI指标相比,DTI指标对地点差异的敏感性较小.
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