生物标志物 生物标志物
Steve Nguyen1, Ake Lu2, Steve Horvath2
1University of California San Diego, La Jolla, CA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
通过AgeAccelGrim2和DunedinPACE测量加速表观遗传衰老,预测老年女性的轻度认知障碍 (MCI) 和痴呆风险. 这些生物年龄估计器可能有助于识别具有较高认知衰退风险的个体.
科学领域:
- 表观遗传学和衰老的研究
- 神经退行性疾病 神经退行性疾病
- 衰老的生物标志物
背景情况:
- 表观遗传年龄估计器评估生物和时间年龄,并将其与心血管疾病和死亡率等健康结果联系起来.
- 很少有大型研究前性地检查了有关轻度认知障碍 (MCI) 或痴呆症的表观遗传年龄估计.
研究的目的:
- 调查多个表观遗传年龄估计器与患MCI或痴呆症的风险之间的关联.
- 评估各种表观遗传加速年龄化措施在大量女性队列中的预测能力.
主要方法:
- 利用了女性健康倡议记忆研究中的5923名女性的数据,在基线没有MCI/痴呆症.
- 计算了Horvath AA,Hannum AA,AgeAccelPheno,内在/外在的表观遗传学AA,AgeAccelGrim2和DunedinPACE. 这三种类型的表观遗传学.
- 采用多变量Cox比例危险模型,并根据人口统计和生活方式因素评估效果的修改.
主要成果:
- 在9.3年的时间里,发生了1267起MCI/痴呆事件.
- 较高的DunedinPACE (HR=1.22) 和AgeAccelGrim2 (HR=1.21) 四分位数与增加的MCI/痴呆风险有关 (p趋势分别为0.02和0.01).
- 对DunedinPACE观察到非线性关联;其他估计器显示没有显著的关联.
结论:
- 由AgeAccelGrim2和DunedinPACE指出的加速表观遗传年龄,预测了老年女性发生的MCI/痴呆症.
- 这些发现表明,表观遗传衰老加速可以作为认知衰退的风险指标.
- 这项研究提供了关于将生物衰老与神经退行联系起来的病理生理机制的见解.
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