生物标志物 生物标志物
1King Chulalongkorn Memorial Hospital, Pathumwan, Bangkok, Thailand.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
肠道微生物组的变化与早期阿尔茨海默病的生物标志物相关,这表明肠道细菌和神经退行之间存在联系. 像益生菌这样的饮食干预可以为老年人提供阿尔茨海默病的预防策略.
科学领域:
- 微生物组研究的研究.
- 神经科学是一个神经科学.
- 老年学是一门学科.
背景情况:
- 老年人肠道微生物组不平衡与阿尔茨海默病 (AD) 通过脑肠轴通信有关.
- 细菌代谢物可能是神经毒性,导致炎症和神经元死亡.
- 饮食显著影响肠道细菌;益生菌和纤维促进有益的细菌.
研究的目的:
- 调查肠道微生物组组成和AD生物标志物之间的相关性.
- 确定与临床前AD相关的特定微生物种群和途径.
- 探索饮食干预在阿尔茨海默病预防方面的潜力.
主要方法:
- 招募了老年参与者 (n=40) 和年龄/性别匹配的对照组 (n=40).
- 分析的血生物标志物:β-粉样蛋白比率 (42/40),p-Tau 181,NFL,GFAP和APOE.
- 在便样本上使用基于amplicon的metagenomics进行了肠道微生物组分析.
主要成果:
- 肠道微生物组特征与血p-tau181和NFL相关.
- 在疾病过程的早期观察到微生物组变化,比其他生物标志物更早.
- 确定了与临床前阿尔茨海默氏症相关的特定肠道类型和途径.
结论:
- 肠道细菌的组成与AD早期进展有关.
- 有益细菌产生抗炎和神经保护性代谢产物.
- 了解肠-大脑轴提供了通过饮食来预防AD的潜在预防策略.
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