生物标志物 生物标志物
Xiaoli Hao1, Xuan Yang1, Lu Shen1
1Xiangya Hospital, Central South University, Changsha, Hunan, China.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
表面电肌图 (sEMG) 通过分析运动变化,有效检测认知障碍 (CI). 将sEMG与血生物标志物的结合显著提高CI和轻度认知障碍 (MCI) 查准确度.
科学领域:
- 神经学 神经学
- 生物医学工程 生物医学工程
- 老年学是指老年学的学科.
背景情况:
- 运动变化往往是认知障碍 (CI) 的前身.
- 表面电肌图 (sEMG) 提供了一种非侵入性的运动评估方法.
- 在检测CI中sEMG的实用性需要进一步澄清.
研究的目的:
- 调查sEMG在识别认知障碍患者中的有效性.
- 探索sEMG特征,认知状态和等离子体生物标志物之间的关系.
主要方法:
- 招募了639名参与者 (284名CI,355名对照) 进行运动和认知评估.
- 在单任务和双任务条件下执行sEMG.
- 在子集中测量了化化181 (p-tau181) 的血含量.
主要成果:
- 康复组织组在运动功能 (如平衡和步行) 中表现出显著的缺陷.
- 20个sEMG特征在CI患者和对照人群之间有显著差异 (p < 0.05).
- 一个组合的sEMG模型实现了高AUC (0.849对于CI,0.875对于MCI),达到0.948与p-tau181用于CI检测.
结论:
- 运动变化在CI患者中始终存在.
- sEMG展示了作为认知障碍查有效工具的潜力.
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