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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

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生物标志物生物标志物

Julie Ottoy¹, Andrew Clappison², Eric Yin²

¹Dr. Sandra E. Black Centre for Brain Resilience and Recovery, Toronto, ON, Canada.

Alzheimer's & dementia : the journal of the Alzheimer's Association

|December 25, 2025

概括

在混合性痴呆症亚型中,粉样蛋白与白质病变有关,而自由水则预测病变随着时间的推移而增长. 了解这些阿尔茨海默病和小血管疾病亚型有助于预测疾病的进展.

科学领域:

神经学神经学
神经成像是一种神经成像.
生物标志物生物标志物

背景情况:

阿尔茨海默氏病 (AD) 是异质的,通常与大脑小血管疾病 (SVD) 一起发生.
之前的研究已经在以AD为重点的队列中使用成像识别了AD亚型.
这项研究定义了不同痴呆症群体的成像亚型,具有不同的SVD负担.

研究的目的:

在低SVD和高SVD痴呆症队列中定义成像衍生的亚型.
为了研究粉样蛋白或自由水在基线和随着时间的推移在这些亚型中预测血管病变 (WMH,PVS).

主要方法:

分析了两个队列中的262名个人:TRIAD (低SVD) 和MITNEC-C6 (高SVD).
使用深度学习细分 (segCSVD) 的量化白质超强度 (WMH) 和扩大周血管空间 (PVS).
使用SuStaIn算法识别疾病亚型,其中包括粉样 SUVR,WMH,PVS和DTI衍生的自由水.

主要成果:

在两个队列中确定了"血管优先"和"混合"亚型;在低SVD队列中发现了"粉样优先"亚型.
粉样蛋白与"混合"亚型中的WMH体积相关;自由水与各亚型中的WMH和PVS体积相关.
基线粉样蛋白预测"血管优先"亚型的WMH增长更快;自由水预测"混合"亚型的WMH增长更快.

结论:

在临床环境中常见的"混合"亚型显示与基线WMH相关的粉样蛋白.
自由水位,而不是粉样蛋白,预测了"混合"亚型的未来WMH增长.
粉样蛋白或自由水没有预测"粉样蛋白第一"亚型的WMH或PVS生长.

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