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生物标志物生物标志物

Grace Austin¹, Shaun Eslick¹, Jessica Ferguson²

¹Macquarie University, Macquarie Park, NSW, Australia.

Alzheimer's & dementia : the journal of the Alzheimer's Association

|December 25, 2025

概括

更高的心血管疾病 (CVD) 风险与增加的神经纤维光链 (NFL) 水平有关,这是神经退行症的标志物. 这表明心血管健康可能会影响大脑健康和阿尔茨海默病 (AD) 途径.

科学领域:

神经科学是一个神经科学.
心脏病学心脏病学
生物标志物研究生物标志物研究

背景情况:

可修改的心血管疾病 (CVD) 风险因素与阿尔茨海默病 (AD) 病原发生有关.
这些因素可能会通过血管机制导致认知衰退和AD病理.
在认知上正常的个体中,CVD风险和血AD生物标志物之间的关联存在有限的研究.

研究的目的:

为了研究预测心血管疾病 (CVD) 风险和血阿尔茨海默病 (AD) 生物标志物之间的关联.
为了确定心血管疾病风险是否与血液中的特定AD相关蛋白质有关.

主要方法:

对237名澳大利亚成年人 (30-75岁) 的横截面分析.
使用已确定的方程计算5年和10年心血管疾病风险得分.
使用SIMOA试验测量血AD生物标志物 (Aβ1-40,Aβ1-42,GFAP,NFL,pTau181) 的结果.
对年龄和性别进行调整的部分相关性分析.

主要成果:

预测较高的5年和10年心血管疾病风险与神经纤维光链 (NFL) 水平显著正相关 (r=0.22-0.23,p<0.001).
在心血管疾病风险和GFAP,Aβ42/40比率或pTau181.1.之间没有发现显著的相关性.
没有观察到心脏代谢风险变量与其他AD生物标志物之间的显著相关性.

结论:

心血管疾病风险升高与NFL增加有关,NFL是一种神经退行生物标志物,独立于年龄和性别.
这表明心血管风险因素可能会显著影响神经退行性途径.
需要进一步的纵向研究来探索心血管疾病风险和AD生物标志物之间的复杂相互作用.

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