Nrf2 作为肺癌中的生物标志物和治疗标,其功能基于图书统计分析和分子机制
Haixia Fan1, Shudan Deng2, Limantian Wang2
1First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Discover oncology
|December 25, 2025
概括
这项文献计量研究映射了肺癌中核因子E2相关因子2 (Nrf2) 的全球研究. 结果揭示了从基础科学到临床应用的不断发展的研究趋势,突出了Nrf2的关键作用.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物信息学是一种生物信息学.
背景情况:
- 肺癌仍然是全球癌症死亡的主要原因.
- 核因子E2相关因子2 (Nrf2) 是一个关键的抗氧化转录因子,与肺癌的发展,进展和治疗抵抗有关.
- 无调节的Nrf2激活显著影响肺癌的发病性.
研究的目的:
- 对肺癌中Nrf2的全球研究环境进行全面的文献计量分析.
- 识别出版趋势,主要贡献者,有影响力的期刊和新兴研究主题.
- 了解Nrf2研究在肺癌中的演变.
主要方法:
- 从Web of Science核心集合和Scopus数据库中检索数据.
- 使用诸如Python,CiteSpace,VOSviewer和R (bibliometrix) 等工具进行图书识别分析.
- 评价出版物生产率,地理分布,机构贡献,作者影响,期刊影响,共同引用网络和关键词分析.
主要成果:
- 总共分析了1931个出版物,从2002年到2025年观察到引用的显著增加.
- 中国在出版量方面处于领先地位,其知名机构和研究人员,如马萨尤基·亚马莫托和夏姆·比斯瓦尔.
- 癌症研究成为最多产的期刊,研究重点从基础研究转移到临床治疗策略和特定的肺癌亚型.
结论:
- 关于Nrf2的肺癌研究已经从基本细胞表征到氧化和编程细胞死亡的研究.
- 未来的研究应该专注于确定Nrf2.2的上游调节者.
- 建议开发针对性Nrf2调节器,用于个性化肺癌治疗.
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