生物标志物 生物标志物
Sidharth P Mishra1,2, Shalini Jain1,2, Dhananjay Yadav1
1Department of Neurosurgery and Brain Repair, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
高度炎症与老年人认知能力下降和痴呆风险增加有关. 特定的肠道细菌变化可能标志着认知障碍的早期迹象,提供潜在的治疗点.
科学领域:
- 神经科学是一个神经科学.
- 微生物组研究的研究.
- 老年学是指老年学的学科.
背景情况:
- 认知衰退和痴呆症在老龄化人口中越来越关注公共卫生问题.
- 认知衰退和慢性炎症的确切原因尚不清楚.
- 肠道微生物组的改变越来越多地与炎症和痴呆风险有关.
研究的目的:
- 为了研究系统性炎症 (互乐金-6) 和老年人认知障碍之间的关系.
- 识别与认知衰退和炎症相关的独特肠道微生物群签名.
主要方法:
- 分析了来自老化肠道和大脑 (MiaGB) 队列中的微生物组的165个样本.
- 使用ELISA测量血中介质素-6 (IL-6) 的测量.
- 通过蒙特利尔认知评估 (MoCA) 调查问卷评估认知功能.
- 用于便微生物组分析的枪支元基因组测序.
主要成果:
- 具有高IL-6水平的个体显示,轻度认知障碍 (MCI) 的患病率是轻度认知障碍的两倍多.
- 特定的肠道细菌,包括Lachnospira,Akkermansia和Subdoligranulum,在患有MCI和高IL-6的个体中减少.
- 在患有MCI和高IL-6的个体中观察到Fusicatenibacter和Prevotella的升高水平.
结论:
- 减少生产丁酸盐的细菌水平和增加潜在的致病性细菌水平与MCI和高IL-6有关.
- 独特的肠道微生物特征可能作为认知衰退的早期生物标志物.
- 这些发现表明,在老年人中,保持大脑健康是潜在的治疗点.
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