生物标志物 生物标志物
Anna M VandeBunte1, Emily W Paolillo1, Rowan Saloner1
1Memory and Aging Center, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
女性积累白质超强度 (WMH) 比男性更快,但高静脉压只能预测男性的WMH. 这突出了大脑衰老和血管贡献的性别特异性因素.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 心血管健康 心血管健康
背景情况:
- 心血管风险概况在整个寿命中表现出性别差异,绝经后的女性经历了增加的血管风险.
- 老年女性的白质超强度 (WMH) 负担比男性高.
- 心血管健康和WMH中的性别差异建议研究它们与WMH积累的关联.
研究的目的:
- 检查心血管风险和白质强度过高 (WMH) 积累之间的性别差异关系.
- 为了调查纵向WMH轨迹是否因性别而有所不同.
- 为了确定基线缩血压是否预测男性和女性的WMH积累不同.
主要方法:
- 262名功能完整的老年人 (平均年龄70.5岁,56%是女性) 接受了基线血压测量和纵向神经成像 (WMH和灰质体积).
- 线性混合效应模型评估了WMH轨迹的性别差异随着时间的推移.
- 相互作用模型测试了基线静脉压和WMH轨迹之间的性别特定关联,并分析了灰质体积的特异性.
主要成果:
- 虽然基线压缩血压和WMH体积并没有因性别而有所不同,但女性随着时间的推移,WMH积累更为急剧.
- 较高的基线缩血压与随着时间的推移增加的WMH负担有关,仅在男性中.
- 静脉压预测了所有参与者的灰质体积损失,但这种效应与性别无差异.
结论:
- 与男性相比,女性随着时间的推移显示出更多的WMH积累.
- 缩血压是男性WMH负担的重要预测因素,这表明其他因素也会影响女性WMH.
- 系统血压与大脑衰老之间的关系中的性别差异似乎是白质的特征.
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