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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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生物标志物 生物标志物

Peiwei Liu1, Jacinda Taggett1, Theresa M Harrison1

  • 1University of California, Berkeley, Berkeley, CA, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
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概括
此摘要是机器生成的。

阿尔茨海默病 (AD) 生物标志物如粉样β (Aβ) 和PET与认知有关,但与ADNI相比,在不同的美国POINTER研究中,相关性较弱. 皮层厚度也显示出在认知中,特别是ADNI中,tau独立的作用.

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科学领域:

  • 神经科学是一个神经科学.
  • 放射学 放射学是一门学科.
  • 老年学是指老年学的学科.

背景情况:

  • 阿尔茨海默病 (AD) 的特点是认知,病理和神经退行之间的联系.
  • 美国POINTER研究,一个高心血管风险的多样性队列,显示tau PET与认知的联系比阿尔茨海默病神经成像计划 (ADNI) 更密切.
  • 在ADNI和POINTER之间生物标志物认知关系的差异需要进一步调查.

研究的目的:

  • 探索美国POINTER和ADNI队列中ADD生物标志物,皮质厚度和认知领域之间的横截面关系的差异.
  • 为了比较粉样β (Aβ) PET,tau PET和皮质厚度如何与不同的研究群体的口头记忆,执行功能和全球认知相关联.

主要方法:

  • 根据年龄,性别,临床状况和APOE4基因型对美国POINTER (N=775) 和ADNI (N=405) 的参与者进行了匹配.
  • 检查了基线Aβ PET,tau PET (POINTER中的MK6240,ADNI中的FTP),区域皮质厚度和认知表现 (口头记忆,执行功能,全球认知) 之间的关联.
  • 在所有分析中对年龄,性别和教育进行控制.

主要成果:

  • 在ADNI中,Aβ负担与更差的执行功能和全球认知相关,但与记忆无关;在POINTER中没有发现这种关联.
  • 在Aβ阳性个体中,tau负担与ADNI的各个领域的表现较差有关,但仅与POINTER的语言记忆较差有关.
  • 在ADNI中观察到皮层厚度与执行功能/全球认知之间的更强的积极关联,独立于tau,这表明厚度的作用与tau无关.

结论:

  • 认知表现与Aβ,tau和皮质厚度的关联在ADNI中始终比POINTER更强,特别是在Aβ阳性个体中.
  • 皮层厚度独立地促进认知功能,不管tau水平如何,特别是在ADNI队列中.
  • 研究结果表明,通常报告的AD生物标志物协会可能会在异质的,社区招募的队列中减弱,如美国POINTER.