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临床表现 临床表现

Rachel N Schade1, Andrew O'Shea2, Katie Rodriguez1

  • 1University of Florida, Gainesville, FL, USA.

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概括
此摘要是机器生成的。

担心主观认知投诉 (SCC) 的老年人表现出空间记忆任务的表现较差,可能与情绪和动机有关,而不是海马体变化. 这表明担心可能表明早期临床前阿尔茨海默病 (AD).

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科学领域:

  • 神经科学是一个神经科学.
  • 认知心理学 认知心理学
  • 老年学是一门学科.

背景情况:

  • 主观认知投诉 (SCC) 与海马体变化和临床前阿尔茨海默病 (AD) 风险增加有关.
  • 患有SCC的个人经历了痛苦 (
  • 担心的担心的担心的担心.
  • ) 可能代表一个具有更高风险的独特子组.
  • 这项研究调查了患有SCC的担心和不担心个体之间的差异.

研究的目的:

  • 为了比较SCC的焦虑和非焦虑个体之间的海马任务性能和体积.
  • 为了确定心情和/或动机是否影响这些群体的认知表现.
  • 探索SCC担忧和临床前AD指标之间的潜在联系.

主要方法:

  • 154名患有SCC的成年人被分为"担心" (N=76) 和"不担心" (N=78) 组.
  • 认知评估包括基于海马的任务 (ARENA,MST).
  • 用ANCOVA和t测试分析了情绪 (BDI-II,AS,STAI) 和海马体积.

主要成果:

  • 担心组在空间导航 (ARENA) 任务中表现明显差,但在模式分离 (MST) 中表现不好.
  • 两组之间没有发现海马体积的显著差异.
  • 担心的人报告了更高水平的抑郁,焦虑和冷漠,冷漠部分调解了ARENA性能差异.

结论:

  • 老年人对SCC的担忧与情绪和动机症状的增加有关,影响认知任务的表现.
  • 空间导航任务 (ARENA) 可能对与情绪相关的认知变化敏感,可能反映早期的AD.
  • 这些发现表明",担心"的SCC组可能代表经历临床前AD变化的个体.