生物标志物 生物标志物
Woo-Jin Cha1, Dahyun Yi2, Evgeny J Chumin3,4
1Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea, Republic of (South).
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
临床前阿尔茨海默病 (AD) 显示,网络内部的默认模式网络 (DMN) 功能连接性 (FC) 增加,网络之间FC降低. 这些变化可能反映了AD早期的补偿性大脑活动.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 放射学 放射学是一门学科.
背景情况:
- 默认模式网络 (DMN) 在早期阿尔茨海默病 (AD) 中受到β-粉样蛋白 (Aβ) 的影响.
- 关于DMN功能连接 (FC) 在AD阶段如何变化的数据有限.
- 这项研究调查了临床前AD的DMN FC变化.
研究的目的:
- 在临床前AD中识别特征性DMN FC变化.
- 为了比较认知正常 (CN),轻度认知障碍 (MCI) 和AD痴呆症组中的DMN FC.
- 探索Aβ沉积和DMN FC之间的关系.
主要方法:
- 396名参与者 (CN,MCI,AD痴呆症) 来自KBASE队列 (年龄55-88岁).
- 使用了PiB PET和静止状态功能性MRI.
- 计算了DMN FC,并根据Aβ阳性分类了参与者 (CN-, CN+, MCI+, AD+).
主要成果:
- 与其他组相比,Aβ+ CN (CN+) 组在DMN内显著显示出更高的FC.
- 与其他组相比,CN+组表现出明显较低的DMN FC.
- 这些发现表明在临床前AD中存在明显的DMN FC模式.
结论:
- 在DMN内增加的FC和在DMN之间减少的FC是临床前AD的特征.
- 这些DMN FC变化可能代表由于早期Aβ沉积而导致的补偿网络激活.
- 需要进一步的研究来证实这些发现及其对阿尔茨海默病进展的影响.
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