临床表现 临床表现
Clive G Ballard1, Ellie Pickering1, Abbie Palmer1
1University of Exeter, Exeter, United Kingdom.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
该PROTECT-UK研究表明,数字平台可以有效地收集纵向数据并对老年人进行远程临床试验. 这种方法确保了高质量的研究,参与者的参与,以及未来研究的成本效益.
科学领域:
- 老年学和衰老研究研究.
- 数字健康和远程医疗.
- 基因组研究和个性化医学
背景情况:
- 保护英国倡议建立了英国成年人的在线队列,以支持大规模,高质量的纵向数据收集.
- 它的目标是为老龄化人口的远程和混合临床试验提供具有成本效益和低风险的解决方案.
研究的目的:
- 评估数字平台对老年成年人纵向数据收集的可行性和有效性.
- 为了促进远程和混合临床试验,提高招聘和保留.
- 为了实现基因组和其他生物样本的收集,用于先进的研究.
主要方法:
- 通过专门的网站和应用程序招聘40岁以上的英国成年人.
- 在线完成年度神经心理评估 (FLAME电池),健康,生活方式和神经心理症状数据.
- 远程DNA收集和使用平台进行临床试验的接触同意和预先查.
- 参与者参与策略,包括认知训练和定期沟通.
主要成果:
- 超过54,000名参与者报名,其中30,000人在英国队列中活跃;挪威和加拿大的国际实例.
- 同比较高的参与者保留率 (高达80%) 和临床试验保留率 (高达95%),数据完整性与人体试验相比较.
- 成功招募超过6万名参与者参加在线试验,包括认知训练和营养补充剂研究 (例如维生素D,酸盐).
- 基因组数据为对精神分裂症,阿尔茨海默氏症风险的研究做出了贡献,并确定了具有GBA突变和APOE4同位素的队列.
结论:
- 数字平台研究可以通过主动策略实现参与者的长期参与.
- 该PROTECT研究验证了远程执行高效,高质量的临床试验.
- 通过数字平台远程收集基因组和生物材料,大大提高了研究成果.
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