一种通用方法来访问无菌阻碍和复杂的以太
Sumit Pareek1, Pavan Mandadi1, Someswara Rao Sanapala1
1Department of Chemistry, Indian Institute of Technology Tirupati, Yerpedu 517619, India.
一种新的无金属还原性乙烯化方法有效合成阻碍的乙烯. 这种可扩展的过程使用二甲基和一种硫氨酸催化剂,提供广泛的基质范围和功能组耐受性.
科学领域:
- 有机化学 有机化学
- 合成化学 合成化学
- 催化剂是一种催化剂.
背景情况:
- 阻乙烯是药物化学和材料科学中有价值的化合物.
- 现有的合成受阻乙烯的方法通常需要恶劣的条件或昂贵的催化剂.
- 开发高效和可扩展的无金属合成路线仍然是一个关键的挑战.
研究的目的:
- 开发一种高效,可扩展和无金属的方法来合成受阻的以太.
- 探索离子结合催化在还原性以太化中的实用性.
- 为了证明新方法的广泛适用性和功能组耐受性.
主要方法:
- 使用二甲基 (CDMS) 作为源的还原性化.
- 使用 Schreiner 硫尿素的催化剂量来激活碳化合物.
- 使用in situ生成的化和离子结合催化,形成氧化碳中间体.
- 促进化物转移以形成以太链接.
主要成果:
- 通过使用无金属的催化系统,成功合成了高效率的受阻.
- 证明了广泛的基质范围,成功反应了89种不同的基质.
- 显示出优异的功能性群体耐受性,包括与类固醇,特类,类和晚期药物修改 (利托纳维尔) 的应用.
结论:
- 开发的还原性乙化方法是高效的,可扩展的,不含金属的.
- 催化系统有效地激活碳基,并促进以太键的形成.
- 这种方法为合成各种化学领域相关的复杂阻碍乙烯提供了一个多功能工具.
更多相关视频
06:31Highly Stereoselective Synthesis of 1,6-Ketoesters Mediated by Ionic Liquids: A Three-component Reaction Enabling Rapid Access to a New Class of Low Molecular Weight Gelators
Published on: November 27, 2015
08:12A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
Published on: August 16, 2018
相关概念视频
Ethers from Alcohols: Alcohol Dehydration and Williamson Ether Synthesis
Ethers can be prepared from organic compounds by various methods. Some of them are discussed below,
Preparation of Ethers by Alcohol Dehydration
In this method, in the presence of protic acids, alcohol dehydrates to produce alkenes and ethers under different conditions. For example, in the presence of sulphuric acid, dehydration of ethanol at 413 K yields ethoxyethane, whereas it yields ethene at 443 K.
Structure and Nomenclature of Ethers
Ethers are organic compounds with an ether functional group which is characterized by an oxygen atom connected to two — identical or different — alkyl, aryl, or vinyl groups. The C–O–C linkage in dimethyl ether — the simplest ether — has an approximately tetrahedral bond angle of 110.3 degrees. The oxygen atom is sp3- hybridized, with the C–O distance being about 140 pm.
Classification of Ethers
Based on their attached substituent...
Ethers from Alkenes: Alcohol Addition and Alkoxymercuration-Demercuration
Ethers can also be prepared from alkenes through acid-catalyzed addition of alcohols and alkoxymercuration–demercuration.
Preparation of Ethers by Acid-Catalyzed Addition of Alcohol to Alkenes
The acid-catalyzed addition of alcohol to an alkene involves treating the alkene with an excess of alcohol in the presence of an acid catalyst to form an ether under suitable conditions. The hydrogen will add to the less substituted carbon so that the nucleophile can attack the more substituted...
Ethers to Alkyl Halides: Acidic Cleavage
Physical Properties of Ethers
An ether molecule has a net dipole moment due to the polarity of C–O bonds. Subsequently, boiling points of ethers are lower than those of alcohols of comparable molecular weight and slightly higher than those of hydrocarbons of comparable molecular weight (Table 1).
Ethers can act as hydrogen bond acceptors, making them more water-soluble than hydrocarbons, but since ethers cannot act as hydrogen bond donors, they are much less soluble in water than alcohols. Ethers are considered...
Autoxidation of Ethers to Peroxides and Hydroperoxides
