生物标志物 生物标志物
Vikas Kotari1, Karen Chilcott Holdridge2, Roy Yaari2
1Eli Lilly and Company, Indianapolis, IN, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
这项研究分析了前临床阿尔茨海默病 (AD) 参与者的定子发射断层扫描 (PET) 扫描. 结果显示tau沉积模式与其他临床前AD队列相似,即使在那些轻度认知障碍的人中也是如此.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 老年学是一门学科.
背景情况:
- 临床前阿尔茨海默氏症 (AD) 的特点是粉样蛋白积累,但保持认知能力.
- 在无症状阿尔茨海默病 (A4) 试验中,大多数参与者缺乏显著的积.
- 在TRAILBLAZER-ALZ 3试验中,研究了donanemab在临床前AD的疗效.
研究的目的:
- 描述和比较TRAILBLAZER-ALZ 3,A4和TRAILBLAZER-ALZ 2研究中的基线定子发射断层扫描 (PET) 扫描.
- 在临床前阿尔茨海默病患者群体中分析tau分布,使用flortaucipir F 18 (FTP) PET扫描.
主要方法:
- 利用了来自TRAILBLAZER-ALZ 3试验的310名参与者的数据,根据临床痴呆症评分-全球分数 (CDR-GS 0和CDR-GS 0.5) 分类.
- 雇佣了flortaucipir F 18 (FTP) tau PET成像和分析全球tau负担和区域模式的建立管道.
- 使用标准化吸收值比率 (SUVR) 切割点定义的tau阳性 (>1.11对于阳性扫描,>1.46对于高tau水平).
主要成果:
- 13.3%的CDR0和25.5%的CDR0.5参与者显示出阳性PET扫描 (SUVR>1.11).
- 在两个小组中,中侧叶表现出最高的区域基线SUVRs.
- 平均SUVRs表明了一种连续的沉积模式:中部 > 侧面 > 顶部 > 前叶.
结论:
- 在TRAILBLAZER-ALZ 3中基线tau PET模式与其他临床前AD种群一致,包括CDR0.5亚组.
- 观察到的沉积模式支持从中间叶到额叶的连续进展.
- 计划进行进一步的区域分析,以更深入地了解分布.
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