生物标志物 生物标志物
Olujide Oyeniran1, Kirsty Donald2, Akintunde Orunmuyi3
1Lawson Health Research Institute, London, ON, Canada.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
非洲面临着相当大的阿尔茨海默病和相关痴呆症 (ADRD) 负担. 弥合神经成像差距需要大量投资于基础设施,技术和培训,以推进整个非洲大陆的痴呆症研究.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 公共卫生 公共卫生
背景情况:
- 预计在未来几十年里,非洲将出现阿尔茨海默病和相关痴呆症 (ADRD) 的高患病率.
- 像MRI和PET这样的神经成像工具对于ADRD的表征至关重要,但在非洲尚未得到充分利用.
- 发展神经成像能力,以在非洲不同的人群中开展痴呆症研究,是非常必要的.
研究的目的:
- 为了确定痴呆症神经成像研究的全球差距.
- 确定阻碍非洲使用神经成像技术的障碍.
- 提出在非洲推进痴呆症神经成像研究的机会.
主要方法:
- 用MRI或PET进行ADRD研究的全球文献和临床试验数据库.
- 估计了研究地点,参与者和研究能力的数量.
- 评估了非洲的成像基础设施,人员需求和相关成本.
主要成果:
- 在全球范围内,ADRD神经成像研究仅集中在49个国家,非洲的研究地点和参与者最少.
- 只有四个非洲国家进行了基于MRI的ADRD研究;没有一个国家发表过PET研究.
- 基础设施的高成本,无线电追踪器和熟练人员的短缺是主要障碍,需要大约293亿美元的投资.
结论:
- 增加对具有成本效益的成像基础设施的投资至关重要.
- 为先进的研究优化现有的临床成像系统至关重要.
- 合作培训计划和区域/全球伙伴关系可以在非洲建立痴呆症成像能力.
相关概念视频
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