生物标志物 生物标志物
Dieu-Trang Fuchs1, Yosef Koronyo1, Miyah R Davis1
1Department of Neurosurgery, Maxine Dunitz Neurosurgical Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
阿尔茨海默病 (AD) 视网膜在视网膜质细胞 (RGCs) 中显示病原性tau,导致显著的RGC损失和细胞死亡. 这种病与疾病严重程度相关,这表明RGCs是潜在的早期AD生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
- 病理学 病理学 病理学
背景情况:
- 阿尔茨海默病 (AD) 与视网膜质细胞 (RGC) 损失有关,影响视力.
- 之前的研究发现,AD视网膜中的致病性tau水平升高,但其在RGC中的存在尚未得到证实.
研究的目的:
- 调查阿尔茨海默氏病中RGCs内的致病性异型的存在和影响.
- 为了确定RGC病症,RGC损失和疾病严重程度之间的关系.
主要方法:
- 使用免疫光和Nissl染色的AD/MCI患者和对照组视网膜截面的分析.
- 定量RGCs (RBPMS+),tau含有物 (pS396-tau,oligo-tau) 和细胞死亡标记物 (细胞亡,GVD-亡).
- RGC病理与大脑病理 (布拉克阶段) 和认知状态的相关性.
主要成果:
- 在MCI和AD视网膜中的RGC中发现了ps396-tau和oligo-tau的第一个证据.
- 在RGCs显著减少 (46-56%),伴随着缩,亡和GVD-necroptosis.
- 增加的负荷RGCs (2.1-3.5倍) 与RGC损失和晚期疾病病理学和认知衰退相关.
结论:
- 异常的异形积聚在MCI和AD的RGC中,通过亡和GVD-necroptosis导致显著的RGC损失.
- RGC病与整体疾病严重程度和认知障碍有关.
- RGC病症为早期AD检测和监测提供了一个潜在的非侵入性生物标志物.
相关概念视频
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516