临床表现 临床表现
Moonil Kang1,2, Cody Karjadi1,3, Ting Fang Alvin Ang3,4,5
1Framingham Heart Study, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
数字认知测试,如数字时钟绘图测试 (dCDT),在早期检测阿尔茨海默病 (AD) 和相关痴呆症 (ADRD) 方面表现有前途. 在没有认知障碍的个体中,更好的dCDT性能与较少的主观认知衰退 (SCD) 和未来痴呆风险有关.
科学领域:
- 神经学 神经学
- 认知科学 认知科学
- 数字健康数字健康
背景情况:
- 与传统方法相比,数字认知评估有可能更早地检测阿尔茨海默病 (AD) 和相关痴呆症 (ADRD).
- 主观认知衰退 (SCD) 是AD/ADRD的公认的临床前标志物.
- 这项研究调查了数字时钟绘图测试 (dCDT) 在识别没有客观障碍的个体认知变化的实用性.
研究的目的:
- 确定dCDT是否与认知不受损 (CU) 个体的主观认知衰退 (SCD) 有关.
- 评估dCDT的表现是否预测未来的客观认知障碍,包括轻度认知障碍 (MCI) 和痴呆症.
- 评估dCDT是否检测到传统神经心理 (NP) 测试所遗漏的微妙认知变化.
主要方法:
- 弗雷明汉心脏研究的纵向研究评估了SCD,NP测试和dCDT的参与者.
- 分析包括CU参与者 (年龄≥60岁) 与SCD状态相匹配.
- 横截面和纵向模型分析了dCDT表现与SCD,MCI,AD和全因痴呆症之间的关联,并对NP表现和其他共变量进行调整.
主要成果:
- 更好的dCDT性能,特别是在绘图效率和信息处理方面,与SCD的几率降低有关.
- 改善的dCDT得分独立预测了患MCI和全因痴呆症的风险较低.
- 传统的NP测试没有显示与SCD或未来认知能力下降的相同关联.
结论:
- 该dCDT与SCD相关,并预测CU个体的未来认知衰退 (MCI,痴呆症).
- dCDT可能会发现微妙的认知变化,表明临床前AD/ADRD错过了传统的NP测试.
- 数字认知评估具有早期发现和监测神经退行性疾病的潜力.
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