生物标志物 生物标志物
Mary K Kramer1, Nicholas J Pyontek1, Nicholas A Rizzi1
1University of Delaware, Newark, DE, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
磁共振弹性图 (MRE) 显示,在无症状个体中,与阿尔茨海默病 (AD) 生物标志物相关的脑度降低. 这表明MRE可以使用可访问的血液测试来检测早期AD相关的机械变化.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物发现发现
- 医疗成像医学成像
背景情况:
- 阿尔茨海默氏病 (AD) 病理,包括粉样和积,可以存在于无症状个体中,这代表了干预的关键窗口.
- 磁共振弹性成像 (MRE) 量化大脑组织的硬性,提供了一种方法来检测与AD相关的早期微观结构变化.
- 海马和脑内皮层 (ERC) 是AD病理早期受到影响的关键区域.
研究的目的:
- 研究由MRE测量的大脑机械特性与基于血的阿尔茨海默病 (AD) 生物标志物之间的关系.
- 确定MRE是否可以检测AD风险较高的个体中海马和ERC的早期微结构变化.
主要方法:
- 来自德拉华州预防阿尔茨海默病纵向研究的12名参与者接受了神经心理测试,血液检查和MRE.
- 使用单分子阵列 (Simoa) 试验量化了血氨基酸β (Aβ) 和酸化 (pTau-181,pTau-217).
- 磁力共振测量了海马体和内腔皮层 (ERC) 的度.
主要成果:
- 海马硬度与血pTau-181和Aβ40水平相反相关.
- ERC度与pTau-181有类似的反相关性,与pTau-217有接近显著的相关性.
- 具有较低AD生物标志物度的个体在海马体和ERC表现出较高的度,这表明生物标志物水平与大脑组织退化之间存在联系.
结论:
- 这项研究是第一个将MRE测量的大脑机械特性与基于血的AD生物标志物联系在一起的研究.
- 降低海马和ERC的刚性表明由于蛋白质积累而导致的微观结构破坏.
- MRE测量显示对蛋白质聚合物对大脑力学影响的敏感性,支持其在早期AD检测中与可访问的血液生物标志物一起使用.
相关概念视频
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
746
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
746
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
511
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
511