生物标志物 生物标志物
Fatemeh Tabassi Mofrad1, John Gallacher2
1University of Oxford, Oxford, United Kingdom.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
大脑衰老涉及灰质缩和体积增加在特定的皮下区域,如尾和尾,表明炎症可能在认知衰退中发挥作用.
科学领域:
- 神经成像是一种神经成像.
- 神经科学是一个神经科学.
- 衰老研究研究 衰老研究
背景情况:
- 与年龄相关的认知衰退会影响独立性和寿命.
- 皮下大脑结构与认知能力的恶化有关.
- 需要对与年龄相关的结构性大脑变化进行全面的记录.
研究的目的:
- 为了绘制下皮层灰质中与年龄相关的体积变化.
- 为了研究年龄和皮层下大脑体积之间的关系.
主要方法:
- 利用了来自46111名健康个体的T1加权结构性脑部扫描.
- 参与者分为中年 (44-60) 和老年 (61-83) 组.
- 采用路径分析来检查与年龄相关的皮质下体积变化,并进行模型适应调整.
主要成果:
- 年龄与右/左骨,骨和左骨的体积增加正相关.
- 年龄与大脑干,左丘脑,右/左桃体和海马体体积的减少负相关.
- 观察到老年人皮下区域的体积差异变化.
结论:
- 与年龄相关的结构性大脑变化包括灰质缩和皮层下区域体积增加.
- 在Caudate,Pallidum和Putamen中增加的体积表明与年龄相关的大脑炎症.
- 这些炎症变化可能会在神经退行性疾病的发病前发生.
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