生物标志物 生物标志物
Durjoy Lahiri1,2,3, Jennifer G Cooper4, Bruna Seixas Lima5,6
1Department of Medicine, Queen's University, Kingston, ON, Canada.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
没有粉样质斑块的阿尔茨海默症患者表现出鲜明的血液生物标志物概况. 化陶 (p-tau),GFAP和NfL水平在粉样蛋白阴性个体中升高,这表明有不同的潜在病理.
科学领域:
- 神经学 神经学
- 生物标志物发现发现
- 神经退行性疾病 神经退行性疾病
背景情况:
- 很大一部分阿尔茨海默氏综合征患者缺乏大脑粉样质斑块.
- 粉样蛋白阳性 (Aβ+) 和粉样蛋白阴性 (Aβ-) 个体之间的病理差异尚未得到充分理解.
- 基于血液的生物标志物可以阐明Aβ-阿尔茨海默氏症的病理生理学.
研究的目的:
- 为了在临床阿尔茨海默症中比较Aβ-和Aβ+亚组之间的基于血液的生物标志物.
- 识别潜在的诊断标记,以区分阿尔茨海默氏症的表型.
主要方法:
- 对抗粉样蛋白临床试验中患者的回顾性图表审查.
- 粉样蛋白-β (Aβ) 状态通过脑脊液分析或PET成像确定.
- 使用 Quanterix Simoa HD-X 进行血分析,检测p-tau 181,p-tau 217,GFAP,NfL 和 TDP-43.
主要成果:
- 在Aβ+ (n=25) 和Aβ- (n=20) 组之间没有显著的人口或认知差异.
- 在Aβ+组中,p-tau 181,p-tau 217,GFAP和NfL度显著更高.
- 虽然Aβ-组的TDP-43度显著更高,但在统计学上并不显著.
结论:
- 鲜明的血液生物标志物概况区分Aβ+和Aβ-阿尔茨海默氏综合征患者.
- 这些发现提供了对粉样蛋白阴性阿尔茨海默氏症亚组的病理生理学的见解.
- 血液生物标志物为了解阿尔茨海默氏症异质性的潜在途径提供了机会.
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