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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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生物标志物 生物标志物

Ashley N Price1,2, Megan Stradtman2,3, Savannah Doster1,2

  • 1University of Rhode Island, Kingston, RI, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
概括
此摘要是机器生成的。

视网膜神经纤维层厚度可以预测在临床前阿尔茨海默病 (AD) 中大脑粉样蛋白的积累. 这项研究发现了视网膜内层与粉样蛋白PET扫描结果之间的显著联系,表明了早期AD检测的潜力.

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科学领域:

  • 眼科医生 眼科 眼科
  • 神经学 神经学
  • 生物标志物发现发现

背景情况:

  • 脑中的β-粉样蛋白 (Aβ) 负担,通过PET扫描测量成百状蛋白,是阿尔茨海默病 (AD) 的关键生物标志物.
  • 谱域光学连贯性断层扫描 (SD-OCT) 显示了视网膜层的稀薄,也与AD相关联.
  • 在临床前的AD中,大脑Aβ负荷和视网膜层厚度之间的关系尚不清楚.

研究的目的:

  • 调查视网膜层厚度与大脑Aβ负担 (半角形值) 之间的关联.
  • 确定特定的视网膜层,可以作为临床前AD的生物标志物.

主要方法:

  • 在40名认知正常成年人 (65-80岁) 上进行了SD-OCT成像.
  • 使用HEYEX软件分析了视网膜层厚度和体积.
  • 粉样蛋白PET扫描 (florbetaben) 在SD-OCT后六周内进行.
  • 线性和逻辑回归,控制年龄,评估视网膜测量和PET结果 (阳性/阴性状态) 之间的关系.

主要成果:

  • 外视网膜神经纤维层 (mRNFL) 厚度显著预测了PET百叶状物值 (p=0.0206).
  • 趋势表明了mRNFL总层厚度/体积和PET百叶状物之间的关系 (p=0.0921,p=0.0679).
  • 外视网膜色素表皮质 (RPE) 厚度和外状层 (OPL) 体积显示了与PET状态的趋势关联 (p=0.0757,p=0.0572).

结论:

  • 在mRNFL厚度和百叶状物值之间显著的关联支持在轻度认知障碍 (MCI) 和AD人群中之前的发现.
  • 这项研究是第一个在临床前AD队列中探索这种关系的研究.
  • 视网膜OPL的发现与先前的研究结合,该研究将OPL厚度与血ptau217联系起来,这是大脑粉样化症的指标. 为了验证,需要进行纵向研究.