生物标志物 生物标志物
Ashley N Price1,2, Megan Stradtman2,3, Savannah Doster1,2
1University of Rhode Island, Kingston, RI, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
视网膜神经纤维层厚度可以预测在临床前阿尔茨海默病 (AD) 中大脑粉样蛋白的积累. 这项研究发现了视网膜内层与粉样蛋白PET扫描结果之间的显著联系,表明了早期AD检测的潜力.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 生物标志物发现发现
背景情况:
- 脑中的β-粉样蛋白 (Aβ) 负担,通过PET扫描测量成百状蛋白,是阿尔茨海默病 (AD) 的关键生物标志物.
- 谱域光学连贯性断层扫描 (SD-OCT) 显示了视网膜层的稀薄,也与AD相关联.
- 在临床前的AD中,大脑Aβ负荷和视网膜层厚度之间的关系尚不清楚.
研究的目的:
- 调查视网膜层厚度与大脑Aβ负担 (半角形值) 之间的关联.
- 确定特定的视网膜层,可以作为临床前AD的生物标志物.
主要方法:
- 在40名认知正常成年人 (65-80岁) 上进行了SD-OCT成像.
- 使用HEYEX软件分析了视网膜层厚度和体积.
- 粉样蛋白PET扫描 (florbetaben) 在SD-OCT后六周内进行.
- 线性和逻辑回归,控制年龄,评估视网膜测量和PET结果 (阳性/阴性状态) 之间的关系.
主要成果:
- 外视网膜神经纤维层 (mRNFL) 厚度显著预测了PET百叶状物值 (p=0.0206).
- 趋势表明了mRNFL总层厚度/体积和PET百叶状物之间的关系 (p=0.0921,p=0.0679).
- 外视网膜色素表皮质 (RPE) 厚度和外状层 (OPL) 体积显示了与PET状态的趋势关联 (p=0.0757,p=0.0572).
结论:
- 在mRNFL厚度和百叶状物值之间显著的关联支持在轻度认知障碍 (MCI) 和AD人群中之前的发现.
- 这项研究是第一个在临床前AD队列中探索这种关系的研究.
- 视网膜OPL的发现与先前的研究结合,该研究将OPL厚度与血ptau217联系起来,这是大脑粉样化症的指标. 为了验证,需要进行纵向研究.
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