生物标志物 生物标志物
Bardiya Ghaderi Yazdi1, Peter Chernek1, Seyed Hani Hojjati1
1Weill Cornell Medicine, New York City, NY, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
正常的衰老不会显著改变大脑网络的稳定性. 健康对照组显示出比认知不受损的老年人更高的边缘网络连接,但这一发现并不强大. 这表明,与年龄相关的功能连接的变化可能受到运动和缩的影响.
科学领域:
- 神经科学是一个神经科学.
- 神经成像是一种神经成像.
- 衰老研究研究 衰老研究
背景情况:
- 网络内部的功能连接 (FC) 对于理解大脑健康和疾病至关重要.
- 不过,与年龄相关的CF变化尚不清楚,因此需要对健康的年轻人和老年人进行研究.
- 这项研究调查了大脑大规模网络连接与衰老的变化.
研究的目的:
- 通过静止状态功能性MRI (rfMRI) 来研究与年龄相关的大脑网络连接的变化.
- 为了比较年轻健康对照 (HC) 中的FC与认知不受损 (CU) 的老年人.
- 为了控制运动和大脑缩对FC的影响.
主要方法:
- 分析了来自60名HC和191名CU参与者的rfMRI数据.
- 使用了全面的fMRI管道,包括运动校正和空间正常化.
- 在七个大规模大脑网络中,使用Pearson的相关性计算了区域间的连接性.
主要成果:
- 在HC和CU集团之间,在整体大规模网络连接方面没有发现显著差异.
- 健康对照人群与CU人群相比,表现出更高的边缘网络 (LIM) FC (p=0.02),即使在控制运动后.
- 粉样蛋白状况和运动排除没有改变主要发现,尽管一项分析显示CU中的LIM FC部分显著上升 (p=0.056).
结论:
- 正常的健康衰老似乎保持大规模大脑网络的稳定性.
- 在其他研究中,随着年龄的增长而观察到的FC下降可能受到运动和大脑缩的影响.
- 需要进一步的研究来澄清衰老对大脑连接的确切影响.
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