生物标志物 生物标志物
Ben Senderling1, Amy Kwok1, Annalisa Na1
1Drexel University, Philadelphia, PA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
本综述总结了阿尔茨海默病和相关痴呆症 (ADRD) 的老年人的关节生物力学. 大多数研究集中在走路上,突出了作为ADRD生物标志物的步态分析的潜力.
科学领域:
- 生物力学 生物力学
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
背景情况:
- 功能活动,特别是步态,越来越多地被认为是阿尔茨海默病和相关痴呆症 (ADRD) 的潜在生物标志物.
- 当前的研究往往强调时空步态参数,忽视了潜在的生物力学因素.
- 了解功能任务期间的联合生物力学对于开发针对ADRD患者的有针对性的干预措施至关重要.
研究的目的:
- 进行对现有的关于ADRD诊断的老年人功能活动期间关节生物力学相关文献的范围审查.
- 确定涉及这一群体的研究中报告的生物力学评估的范围和性质.
主要方法:
- 根据PRISMA-ScR指南进行了全面的范围审查.
- 从最初到2024年12月,主要的在线数据库 (Ovid,Embase,Scopus,Web of Science) 进行了搜索.
- 包括65岁以上ADRD成年人关节生物力学量化的研究,由两个独立审查员进行查和数据图表.
主要成果:
- 该审查在1069个初步结果中确定了18项符合条件的研究,其中大多数研究是在2016年后发表的.
- 大多数研究采用横截面设计,重点关注步行 (13项研究) 作为主要的功能活动.
- 用运动捕捉和惯性传感器评估下肢关节生物力学 (脚,膝盖,部),量化角度和时刻.
结论:
- 最近的研究主要检查 ADRD 的一种形式,即轻度认知障碍 (MCI) 的老年人行走时的下肢生物力学.
- 这些发现表明,需要对这群人群中行走生物力学进行系统评估.
- 进一步的系统审查可以提高对步态作为ADRD生物标志物的理解,并为干预策略提供信息.
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