生物标志物 生物标志物
Gurveen Kaur Sandhu1, Jacklyn Leonardo1, Fatin Zahra Zailan1
1Dementia Research Centre (Singapore), Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
神经纤维光链 (NfL) 在轻度认知障碍 (MCI) 和高白质超强度 (WMH) 的年轻成年人中升高. 这种NFL在老年人中增加了高原,这表明NFL在老年人中增加了高原.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物 生物标志物
- 老年学是一门学科.
背景情况:
- 神经纤维光链 (NfL) 是神经元中的关键结构蛋白,在白质超强度 (WMH) 的条件下经常升高.
- 轻度认知障碍 (MCI) 的年轻人与老年人的NfL水平,WMH负担和认知功能之间的关系需要进一步调查.
- 这项研究重点关注东南亚MCI社区队列,其中大脑血管疾病负担很大.
研究的目的:
- 调查NfL度,WMH负担和MCI的东南亚年轻和年长成年人的认知状态之间的关联.
- 探索NfL作为潜在的生物标志物的作用,用于早期检测白质疾病和认知衰退.
主要方法:
- 一项对310名被诊断患有MCI的东南亚社区参与者的横截面研究.
- 参与者根据WMH负担进行了分层,使用修改后的Fazekas尺度.
- 使用视觉认知评估测试 (VCAT) 评估全球认知,并使用Simoa平台测量血NfL水平.
主要成果:
- 在患有MCI的年轻人中,高WMH负担与增加的NfL,较差的认知和更大的周围血管空间相关.
- 在患有MCI的老年人中,高WMH负担与大脑血管疾病标志物的增加有关,包括血压,周血管空间,缺口性心脏病发作,中间时缩和灰质减少.
- 与年轻组相比,在较老的MCI组中观察到NfL增加的平原.
结论:
- 升高的NfL与MCI的东南亚年轻成年人中高WMH负担有关.
- 在老年人中观察到的NfL增加平原可能表明值效应或神经生物学能力下降.
- 在东南亚人中,NfL显示为早期检测和预测白质疾病和认知障碍的生物标志物.
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