生物标志物 生物标志物
Emma F Bublitz1,2,3,4, Carol A Van Hulle3, Hannah Zylstra5
1University of Wisconsin-Madison, Madison, WI, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
伊科萨乙烯 (IPE) 在退伍军人中没有显著改变大脑血流. 然而,基线血管大脑脊髓液 (CSF) 生物标志物与血液流量测量相关,与APOE ε4载体状态不同.
科学领域:
- 神经科学是一个神经科学.
- 心血管医学 心血管医学
- 放射学 放射学是指放射学
背景情况:
- 退伍军人患血管疾病和阿尔茨海默氏病 (AD) 的风险更高.
- 伊科萨乙烯 (IPE) 是一种omega-3脂肪酸,可以减少心血管事件和甘油三.
- 脑血管健康可能会影响AD风险,4D流动MRI (PCVIPR) 可以评估大脑血流和动脉硬度.
研究的目的:
- 为了研究IPE对退伍军人的脑血管健康的影响,使用4D流动MRI (PCVIPR).
- 在退伍军人中探索IPE,APOE基因型和脑脊液 (CSF) 生物标志物的关系.
主要方法:
- BRAVE-EPA研究是一项随机,双盲,安慰剂控制的试验,涉及123名认知不受损的退伍军人.
- 参与者每天接受4克IPE或安慰剂18个月,接受PCVIPRMRI和CSF生物标志物分析.
- 图像分析的重点是平均血流量 (MF),脉动性指数 (PI) 和总脑血流量 (CBF).
主要成果:
- 在18个月内,IPE治疗并没有显著改变MF,PI或CBF测量.
- APOE ε4 携带者和非携带者表现出类似的基线血流.
- 基线CSF血管生物标志物与PI显著相关,并且在较小程度上与MF相关.
结论:
- 在这组退伍军人中,IPE治疗没有显著影响PCVIPR测量脑血流的脑血流量.
- 基线CSF血管生物标志物水平,而不是APOE ε4状态,与基线脑血流量指标有关.
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