生物标志物 生物标志物
Emma Ruppert1, Marina Scop Medeiros1, Marie R Vermeiren2
1University of Pittsburgh, Pittsburgh, PA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
一种新的统一视觉阅读方法对tau-PET标记剂显著改善了inter-rater和inter-tracer协议. 这种临床医生友好的方法协调了tau沉积评估,提高了阿尔茨海默病的诊断一致性.
科学领域:
- 神经成像是一种神经成像.
- 核医学是一种核医学.
- 放射化学 放射化学是指辐射化学.
背景情况:
- 定子发射断层扫描 (PET) 成像对于可视化大脑中的病理至关重要.
- 将研究成果纳入临床实践,特别是通过视觉阅读,对于推进患者护理至关重要.
- 对于像[18F]Flortaucipir (FTP) 和[18F]MK-6240 (MK) 这样的tau PET标记物的现有视觉读取方法需要进行比较和协调.
研究的目的:
- 为了比较FTP和MK tau-PET追踪器当前视觉读取方法的性能.
- 开发和验证所有tau-PET标记物的统一视觉读取方法.
- 提供初步数据,用于对陶沉积的标准化视觉评估.
主要方法:
- 两名盲人评级人员使用既有方法评估了HEAD研究中340名参与者的FTP和MK视觉阅读.
- 开发了一种新的统一视觉阅读方法,并对101名参与者进行了测试,协调了标志物,并使用调整的布拉克区域进行严重程度分期.
- 计划在四个额外的队列中使用FTP,MK,PI或RO追踪器进行外部验证.
主要成果:
- 之前的方法显示,对低/高tau负担的一致性很高,但对非AD类类别的一致性较低 (0.55-0.69).
- 开发的统一方法显著改善了评价者之间的协议 (0.87-0.96) 并引入了适度的tau负担类别.
- 随着新方法的使用,标记物间的不一致性从24.7%-34.4%下降到11.9%-15.8%,这表明一致性有所提高.
结论:
- 对于tau-PET标记物的现有视觉读取方法,根据所使用的标记物产生不同的结果.
- 拟议的统一方法增强了互评价和互追踪协议,提供了一种标准化的方法.
- 这种临床医生友好的,可追踪剂不可知技术有可能在tau-PET解释中得到广泛的临床采用.
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